Recombinant Human PATZ1 Protein, HIS-tagged

• Cat.No.: PATZ1-049H
• Product Overview: Recombinant Human PATZ1, transcript variant 4, fused with HIS tag at N-terminal was expressed in E. coli.

Specification

• Description: The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
• Source: E. coli
• Species: Human
• Tag: HIS
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl. Store at -80centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 57.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: PATZ1 POZ (BTB) and AT hook containing zinc finger 1 [ Homo sapiens ]
• Official Symbol: PATZ1
• Synonyms: PATZ1; POZ (BTB) and AT hook containing zinc finger 1; zinc finger protein 278 , ZNF278; POZ-, AT hook-, and zinc finger-containing protein 1; dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZSG; MAZ-related factor; zinc finger protein 278; POZ-AT hook-zinc finger protein; zinc finger sarcoma gene protein; BTB-POZ domain zinc finger transcription factor; BTB/POZ domain zinc finger transcription factor; zinc finger and BTB domain-containing protein 19; protein kinase A RI subunit alpha-associated protein; ZNF278
• Gene ID: 23598
• mRNA Refseq: NM_014323
• Protein Refseq: NP_055138
• MIM: 605165
• UniProt ID: Q9HBE1