| Description : |
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
90.3 kDa |
| AA Sequence : |
MAALQKLPHCRKLVLLCFLLATLWE ARAGQIRYSVREEIDRGSFVGNIAK DLGLEPLALAEQGVRIVSRGRSQLF ALNPRSGSLVTANRIDREELCAQSA PCLLNFNILLEDKLTIYSVEVEITD INDNAPRFGVEELELKISETTTPGF RIPLKNAHDADVGENALQKYALNPN DHFSLDVRRGADGNKYPELVLERSL DREEEAVHHLVLVASDGGDPVLSGT SRICVKVLDANDNAPVFTQPEYRIS IPENTLVGTRILTVTATDADEGYYA QVVYFLEKSPGETSEVFELKSTSGE LTIIKDLDYEDATFHEIDIEAQDGP GLLTRAKVIVTVLDVNDNAPEFYMT SATSSVSEDSLPGTIIGLFNVHDRD SGQNAFTTCSLPEDLPFKLEKSVDN YYRLVTTRALDREQFSFYNITLTAK DGGNPSLSTDAHILLQVADINDNAP AFSRTSYSTYIPENNPRGASVFSVT AHDPDSNDNAHVTYSFAEDTVQGAP LSSYISINSDTGVLYALRSFDYEQL RDLQVWVIARDSGNPPLSSNVSLSL FVLDQNDNAPEILYPAFPTDGSTGV ELAPRSAEPGYLVTKVVAVDRDSGQ NAWLSYHLLKASEPGLFSVGLHTGE VRTARALLDRDALKQSLVVAIQDHG QPPLSATVTLTVAVADRIPDILADL GSLEPSAIPNDSDLTLYLVVAVAAV SCVFLAFVIVLLAHRLRRWHKSRLL QASGGSLTGMQSSHFVGVDGVRAFL QTYSHEVSLTADSRKSHLIFPQPNY ADTLISQESCEKKDFLSAPQSLLEE EREETFSQVIYLFTTYVLASLLKTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
