Recombinant Human PCDHGA6 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human PCDHGA6 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : PCDHGA6-4444H
Product Overview : PCDHGA6 MS Standard C13 and N15-labeled recombinant protein (NP_061742) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 97.7 kDa
AA Sequence : MAPPQRHPQR SEQVLLLTLL GTLWGAAAAQ IRYSIPEELE KGSFVGNIVK DLGLEPQELA EHGVRIVSRG RMQLFSLNPR NGSLVTAGRI DREELCAQSP RCLVSFNILV EDKLNLYPVE VEIVDINDNT PRFLKEELEV KILENAAPSS RFPLMEVYDP DVGMNSLQGF KLSGNSHFSV DVQSEAHGPK YPELVLEGTL DREGEAVYRL VLTAMDGGDP VRSSVAQILV TVLDVNDNTP MFTQPVYRVS VPENLPVGTP VLAVTATDQD EGVHGEVTYS FVKITEKISQ IFCLNVLTGE ISTSANLDYE DSSFYELGVE ARDGPGLRDR AKVLITILDV NDNVPEVVVT SGSRTIAESA PPGTVIALFQ VFDRDSGLNG LVTCSIPRSL PFELEKSVGN YYRLVTNAAL DREEVFLYNI TVTATDKGTP PLSTETIISL NVADTNDNPP TFPHSSYSVY VLENNPRGAS IFSVNALDPD VDQNAQVSYS LAEDTLQGAP LSSYVSINSD TGILYALRSF DYEQLRDLQL WVTASDSGDP PLSSNVSLSL FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG QPPLSATVTL TVAVADRIPD ILADLGSLEP SAKPNDSDLT LYLVVAVAAV SCVFLAFVIV LLALRLQRWH KSRLLQASGG GLASMPGSHF VGVEGVRAFL QTYSHEVSLT ADSRKSHLIF PQPNYADTLI NQESYEKSEP LLITQDLLET KGEPRQLQQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KKTRTRPLEQ KLISEEDLAA NDILDYKDDD DKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : PCDHGA6 protocadherin gamma subfamily A, 6 [ Homo sapiens (human) ]
Official Symbol : PCDHGA6
Synonyms : PCDHGA6; protocadherin gamma subfamily A, 6; protocadherin gamma-A6; PCDH GAMMA A6; PCDH-GAMMA-A6;
Gene ID : 56109
mRNA Refseq : NM_018919
Protein Refseq : NP_061742
MIM : 606293
UniProt ID : Q9Y5G7

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