Recombinant Human PDCD1, His-tagged, Biotinylated

Cat.No. : PDCD1-257H
Product Overview : Human PD-1 /PDCD1 Protein, Biotinylated (Biotinylated PD-1 / PDCD1) Pro 21 - 167 Gln, was labeled with biotin based on rhPD1 Protein, which was produced in human 293 cells (HEK293).
Availability December 09, 2024
Unit
Price $159
Qty
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose are added as protectants before lyophilization.
Molecular Mass : Biotinylated PD-1 / PDCD1, fused with 6×His tag at the C-terminus, has a calculated MW of 17.3 kDa. The predicted N-terminus is Pro 21. DTT-reduced Protein migrates as 38-42 kDa due to glycosylation.
Endotoxin : Less than 1.0 EU per μg of the Biotinylated PD-1 / PDCD1 by the LAL method.
Purity : >95% as determined by reduced SDS-PAGE.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).
Protein length : Pro21-167Gln
Gene Name : PDCD1 programmed cell death 1 [ Homo sapiens ]
Official Symbol : PDCD1
Synonyms : PDCD1; programmed cell death 1; programmed cell death protein 1; CD279; PD1; protein PD-1; PD-1; SLEB2; hPD-1; hPD-l;
Gene ID : 5133
mRNA Refseq : NM_005018
Protein Refseq : NP_005009
MIM : 600244
UniProt ID : Q15116
Chromosome Location : 2q37.3
Pathway : Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem; T cell receptor signaling pathway, organism-specific biosystem;
Function : protein binding; protein tyrosine phosphatase activity; signal transducer activity;

Not For Human Consumption!

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
06/06/2021

    Timely antibody validation, a valuable asset for our laboratory.

    02/12/2021

      Precise protein quantification, fundamental for maintaining data accuracy.

      06/20/2019

        Dependable peptide synthesis, accelerates our peptide-based projects effectively.

        Q&As (14)

        Ask a question
        What are the mechanisms by which PDCD1 modulates the immune response to viral infections? 07/31/2022

        PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

        What are the mechanisms by which PDCD1 modulates the immune response to viral infections? 11/09/2021

        PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

        What role does PDCD1 play in the development of immune tolerance? 10/15/2021

        PDCD1 helps develop immune tolerance, preventing overactive immune responses.

        How does PDCD1 influence the balance between immune activation and autoimmunity? 05/23/2021

        PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

        How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer? 08/13/2020

        PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

        How does PDCD1 influence the balance between immune activation and autoimmunity? 08/05/2020

        PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

        What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers? 12/05/2019

        PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

        How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer? 11/21/2019

        PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

        How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells? 04/24/2019

        PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

        What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers? 01/19/2019

        PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

        What role does PDCD1 play in the development of immune tolerance? 12/08/2018

        PDCD1 helps develop immune tolerance, preventing overactive immune responses.

        How do alterations in PDCD1 expression or signaling affect autoimmune disease progression? 06/24/2018

        Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.

        How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells? 06/24/2018

        PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

        How do alterations in PDCD1 expression or signaling affect autoimmune disease progression? 02/06/2018

        Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.

        Ask a Question for All PDCD1 Products

        Required fields are marked with *

        My Review for All PDCD1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends