Recombinant Human PDCD1 Protein, C-6His-Avi tagged, Biotinylated
| Cat.No. : | PDCD1-15H |
| Product Overview : | Biotinylated Recombinant Human Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Pro21-Gln167 is expressed with a 6His, Avi tag at the C-terminus. |
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| Description : | Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function. |
| Source : | Human Cells |
| Species : | Human |
| Tag : | His&Avi |
| Protein length : | Pro21-Gln167 |
| Endotoxin : | Less than 0.1 ng/μg (1 EU/μg) |
| Storage Buffer : | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Shipping : | Ambient |
| Gene Name : | PDCD1 programmed cell death 1 [ Homo sapiens (human) ] |
| Official Symbol : | PDCD1 |
| Synonyms : | Programmed cell death protein 1; hPD-1; PDCD1; CD279 |
| Gene ID : | 5133 |
| mRNA Refseq : | NM_005018 |
| Protein Refseq : | NP_005009 |
| MIM : | 600244 |
| UniProt ID : | Q15116 |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewTimely antibody validation, a valuable asset for our laboratory.
Precise protein quantification, fundamental for maintaining data accuracy.
Dependable peptide synthesis, accelerates our peptide-based projects effectively.
Q&As (14)
Ask a questionPDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.
PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.
PDCD1 helps develop immune tolerance, preventing overactive immune responses.
PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.
PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.
PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.
PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.
PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.
PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.
PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.
PDCD1 helps develop immune tolerance, preventing overactive immune responses.
Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.
PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.
Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.
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