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Recombinant Human PDGFC Protein, His-tagged

Cat.No. : PDGFC-517H
Product Overview : Recombinant Human PDGFC (NP_057289.1) (Val235-Gly345) was expressed with a polyhistidine tag at the N-terminus.
Description : PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological pr centigradeesses including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A,-B,-C and-D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma pathways. PDGF-C acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. PDGF-C Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic pr centigradeesses, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition centigradecurs.
Source : Yeast
Species : Human
Tag : His
Predicted N Terminal : 0
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant human PDGFC consists of 126 amino acids and predicts a molecular mass of 14.4 kDa.
Protein length : Val235-Gly345
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 97 % as determined by SDS-PAGE.
Storage : Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name : PDGFC platelet derived growth factor C [ Homo sapiens ]
Official Symbol : PDGFC
Synonyms : PDGFC; platelet derived growth factor C; platelet-derived growth factor C; fallotein; SCDGF; PDGF-C; VEGF-E; spinal cord-derived growth factor; secretory growth factor-like protein; FALLOTEIN;
Gene ID : 56034
mRNA Refseq : NM_016205
Protein Refseq : NP_057289
MIM : 608452
UniProt ID : Q9NRA1

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