| Description : |
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized from a 0.2 µM filtered solution of 20mM PB, 150mM NaCl, pH 7.2 |
| Molecular Mass : |
57.17kD |
| AA Sequence : |
LVVTPPGPELVLNVSSTFVLTCSGS APVVWERMSQEPPQEMAKAQDGTFS SVLTLTNLTGLDTGEYFCTHNDSRG LETDERKRLYIFVPDPTVGFLPNDA EELFIFLTEITEITIPCRVTDPQLV VTLHEKKGDVALPVPYDHQRGFFGI FEDRSYICKTTIGDREVDSDAYYVY RLQVSSINVSVNAVQTVVRQGENIT LMCIVIGNEVVNFEWTYPRKESGRL VEPVTDFLLDMPYHIRSILHIPSAE LEDSGTYTCNVTESVNDHQDEKAIN ITVVESGYVRLLGEVGTLQFAELHR SRTLQVVFEAYPPPTVLWFKDNRTL GDSSAGEIALSTRNVSETRYVSELT LVRVKVAEAGHYTMRAFHEDAEVQL SFQLQINVPVRVLELSESHPDSGEQ TVRCRGRGMPQPNIIWSACRDLKRC PRELPPTLLGNSSEEESQLETNVTY WEEEQEFEVVSTLRLQHVDRPLSVR CTLRNAVGQDTQEVIVVPHSLPFVD HHHHHH |
| Endotoxin : |
Endotoxin level is <0.1 ng/µg of protein (<1EU/µg). |
| Purity : |
>95% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration : |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
