PDGFRB

  • Official Full Name

    platelet derived growth factor receptor, beta polypeptide

  • Overview

    The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
  • Synonyms

    PDGFRB; platelet derived growth factor receptor, beta polypeptide; beta-type platelet-derived growth factor receptor; CD140B; Beta platelet derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD 140B; CD140 antigen-like family member B; CD140b antigen; JTK12; OTTHUMP00000160528; PDGF R beta; PDGF-R-beta; PDGFR; PDGFR1; PDGFRB; PGFRB_HUMAN; Platelet derived growth factor receptor beta; Platelet derived growth factor receptor beta polypeptide; PDGF-R-beta; PDGF beta chain; OTTMUSP00000015854; OTTMUSP00000015855; CD140 antigen-like family member B; platelet-derived growth factor receptor beta variant 1; Pdgfr; CD140b; AI528809;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Cynomolgus Monkey
  • Human
  • Human
  • Monkey
  • Mouse
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Zebrafish
  • CHO cells
  • E.coli
  • HEK293
  • HEK293 Cells
  • HEK293T
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Sf21
  • Sf9 Insect Cell
  • C
  • hIgG
  • His
  • DDK
  • DDK|His
  • ENLYFQ
  • Fc
  • Avi
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • hFc
  • His (Fc)
  • human|IgG1|Fc
  • Myc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDGFRB-051H Active Recombinant Human PDGFRB protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi Leu33-Lys531
Human PDGFRB-2187H Active Recombinant Human PDGFRB protein(Met1-Lys531), His-tagged HEK293 C-His Met1-Lys531
Human PDGFRB-544HFL Active Recombinant Full Length Human PDGFRB Protein, C-Flag-tagged Mammalian cells Flag
Human PDGFRB-33H Active Recombinant Human PDGFRB Protein, His-tagged, Biotinylated HEK293 Cells His Met1-Lys531
Human PDGFRB-0269H Active Recombinant Human PDGFRB protein, His-tagged, Biotinylated HEK293 His Met1-Lys531
Human PDGFRB-187H Active Recombinant Human PDGFRB(557-end) Protein, N-His-tagged Sf21 His 557-end
Human PDGFRB-386H Recombinant Human PDGFRB, GST-tagged, Active Sf9 Insect Cell GST
Human PDGFRB-1675H Recombinant Human PDGFRB Mammalian cells N/A
Human PDGFRB-4758H Recombinant Human Platelet-Derived Growth Factor Receptor, Beta Polypeptide, His-tagged HEK293 His
Human PDGFRB-471H Recombinant Human PDGFRB, ENLYFQ tagged Human Cell His
Human PDGFRB-148H Recombinant Human PDGFRB Protein, DDK/HIS-tagged HEK293 DDK/His Leu33 – Val532
Human PDGFRB-184H Recombinant Human PDGFRB protein, Fc-tagged HEK293 human/IgG1/Fc Leu33-Phe530
Human PDGFRB-1890H Recombinant Human Platelet-Derived Growth Factor Receptor, Beta Polypeptide, His-tagged Insect Cell His
Human PDGFRB-3843H Recombinant Human PDGFRB, Fc-His tagged Human Cell Fc/His
Human PDGFRB-151H Recombinant Human PDGFRB Protein, His-tagged Human Cells His
Human PDGFRB-050H Recombinant Human PDGFRB Protein HEK293 N/A
Human PDGFRB-149H Recombinant Human PDGFRB Protein, DDK-tagged Insect Cell DDK Met-Leu33-Val532
Human PDGFRB-150H Recombinant Human PDGFRB Protein, His-tagged HEK293 His
Human PDGFRB-1107HCL Recombinant Human PDGFRB cell lysate Human Cell N/A
Human PDGFRB-175H Recombinant Human PDGFRB Protein, ENLYFQ-tagged HEK293 ENLYFQ Met 1-Lys 531
Human PDGFRB-415H Recombinant Human PDGFRB Protein, His-tagged HEK293 His 1106
Human PDGFRB-271H Recombinant Human PDGFRB Protein (ECD) (Glu241Asp), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Leu33-Phe530 (Glu241Asp)
Human PDGFRB-2058H Recombinant Human PDGFRB Protein, Fc/His-tagged HEK293 Fc/His Leu33-Phe530
Human PDGFRB-471HAF488 Recombinant Human PDGFRB Protein, ENLYFQ-tagged, Alexa Fluor 488 conjugated HEK293 ENLYFQ 506
Human PDGFRB-416H Recombinant Human PDGFRB Protein, Fc-tagged HEK293 Fc 1106
Human PDGFRB-2187HAF488 Recombinant Human PDGFRB Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 510
Human PDGFRB-619H Recombinant Human PDGFRB protein, His-Avi-tagged HEK293 His-Avi Leu 33-Phe 530
Human PDGFRB-2187HAF555 Recombinant Human PDGFRB Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 510
Human PDGFRB-0755H Recombinant Human PDGFRB Protein (Leu33-Phe530), N-His tagged E.coli N-His Leu33-Phe530
Human PDGFRB-2137H Recombinant Human PDGFRB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PDGFRB-675H Recombinant Human PDGFRB Protein HEK293 N/A Met1-Lys531
Human PDGFRB-3843HAF555 Recombinant Human PDGFRB Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 747
Human PDGFRB-129H Recombinant Human PDGFRB Protein (33-532aa), C-hIgG-His tagged Insect Cell C-hIgG-His 33-532aa
Human PDGFRB-472H Recombinant Human PDGFRB protein (Met1-Lys531) HEK293
Human PDGFRB-3843HAF488 Recombinant Human PDGFRB Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 747
Human PDGFRB-471HAF647 Recombinant Human PDGFRB Protein, ENLYFQ-tagged, Alexa Fluor 647 conjugated HEK293 ENLYFQ 506
Human PDGFRB-4847H Recombinant Human PDGFRB Protein (Met1-Lys531), C-His tagged Mammalian cells C-His Met1-Lys531
Human PDGFRB-0641H Active Recombinant Human PDGFRB protein, Fc-tagged HEK293 Fc Leu33-Phe530
Human PDGFRB-2657H Active Recombinant Human PDGFRB protein, hFc&His-tagged HEK293 hFc&His Leu33-Phe530 (Glu241Asp)
Human PDGFRB-471HF Recombinant Human PDGFRB Protein, ENLYFQ-tagged, FITC conjugated HEK293 ENLYFQ 506
Human PDGFRB-4848H Recombinant Human PDGFRB Protein (Leu33-Phe530), C-His tagged E.coli C-His Leu33-Phe530
Human PDGFRB-1634H-B Recombinant Human PDGFRB Protein Pre-coupled Magnetic Beads HEK293
Human PDGFRB-5633H Recombinant Human PDGFRB protein, His-GST-tagged E.coli N-His-GST 901-1106aa
Human PDGFRB-619HB Recombinant Human PDGFRB protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Leu 33-Phe 530
Human PDGFRB-471HAF555 Recombinant Human PDGFRB Protein, ENLYFQ-tagged, Alexa Fluor 555 conjugated HEK293 ENLYFQ 506
Human PDGFRB-2187HF Recombinant Human PDGFRB Protein, His-tagged, FITC conjugated HEK293 His 510
Human PDGFRB-2187HAF647 Recombinant Human PDGFRB Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 510
Human PDGFRB-2573H Recombinant Human PDGFRB Protein, His-tagged E.coli N-His Leu90-Pro344
Human PDGFRB-3843HAF647 Recombinant Human PDGFRB Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 747
Human PDGFRB-1634H Recombinant Human PDGFRB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PDGFRB-3843HF Recombinant Human PDGFRB Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 747
Mouse Pdgfrb-8341M Active Recombinant Mouse Pdgfrb Mammalian cells N/A
Mouse Pdgfrb-01M Active Recombinant Mouse Pdgfrb Protein, His-Tagged NS0 His
Mouse Pdgfrb-10607M-B Recombinant Mouse Pdgfrb Protein Pre-coupled Magnetic Beads HEK293
Mouse Pdgfrb-4759M Recombinant Mouse Pdgfrb Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Pdgfrb-10607M Recombinant Mouse Pdgfrb Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pdgfrb-189M Recombinant Mouse Pdgfrb Protein, His-tagged E.coli His Val337~Pro583
Rat Pdgfrb-306R Active Recombinant Rat Pdgfrb Protein, hFc-tagged HEK293 hFc Met1-Lys530
Rat Pdgfrb-36R Recombinant Rat Pdgfrb, Fc tagged Human Cell His
Rat Pdgfrb-8786R Recombinant Rat Pdgfrb protein(Met1-Lys530), His-tagged HEK293 C-His Met1-Lys530
Rat PDGFRB-4340R Recombinant Rat PDGFRB Protein Mammalian Cell His
Rat PDGFRB-1112RCL Recombinant Rat PDGFRB cell lysate Human Cell N/A
Rat PDGFRB-4000R Recombinant Rat PDGFRB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Pdgfrb-36RAF488 Recombinant Rat Pdgfrb Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 740
Rat Pdgfrb-8786RF Recombinant Rat Pdgfrb Protein, His-tagged, FITC conjugated HEK293 His 510
Rat Pdgfrb-36RAF647 Recombinant Rat Pdgfrb Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 740
Rat Pdgfrb-8786RAF488 Recombinant Rat Pdgfrb Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 510
Rat Pdgfrb-8786RAF555 Recombinant Rat Pdgfrb Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 510
Rat Pdgfrb-36RAF555 Recombinant Rat Pdgfrb Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 740
Rat Pdgfrb-36RF Recombinant Rat Pdgfrb Protein, Fc-tagged, FITC conjugated HEK293 Fc 740
Rat Pdgfrb-8786RAF647 Recombinant Rat Pdgfrb Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 510
Rat PDGFRB-4000R-B Recombinant Rat PDGFRB Protein Pre-coupled Magnetic Beads HEK293
Monkey PDGFRB-1207RAF647 Active Recombinant Monkey PDGFRB Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Met1-Phe530, 509
Monkey PDGFRB-1207RAF488 Active Recombinant Monkey PDGFRB Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Met1-Phe530, 509
Monkey PDGFRB-1207RF Active Recombinant Monkey PDGFRB Protein, His-tagged, FITC conjugated HEK293 His Met1-Phe530, 509
Monkey PDGFRB-1207RAF555 Active Recombinant Monkey PDGFRB Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Met1-Phe530, 509
Monkey PDGFRB-1208RAF488 Recombinant Monkey PDGFRB Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 739
Monkey PDGFRB-1208RAF555 Recombinant Monkey PDGFRB Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 739
Monkey PDGFRB-1208RF Recombinant Monkey PDGFRB Protein, Fc-tagged, FITC conjugated HEK293 Fc 739
Monkey PDGFRB-1208RAF647 Recombinant Monkey PDGFRB Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 739
Cynomolgus Monkey PDGFRB-111C Recombinant Cynomolgus PDGFRB, His tagged Human Cell His
Cynomolgus Monkey PDGFRB-1046CCL Recombinant Cynomolgus PDGFRB cell lysate Human Cell N/A
Rhesus PDGFRB-1208R Active Recombinant Rhesus PDGFRB protein, hFc-tagged HEK293 hFc Met1-Phe530
Rhesus Macaque PDGFRB-1207R Active Recombinant Rhesus PDGFRB protein, His-tagged HEK293 His Met1-Phe530
Zebrafish PDGFRB-7777Z Recombinant Zebrafish PDGFRB Mammalian Cell His
Kit-1618 PDGFRb Functional Assay Kit N/A
Kit-1617 U2OS PDGFRb Bioassay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PDGFRB involved in several pathways and played different roles in them. We selected most pathways PDGFRB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFRB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPdgfa&Pdgfb;MAPK1;MEF2CB;MAPKAPK3;MAP3K12;TGFB1;RPS6KA3A;FGF6A;MAP2K2
Ras signaling pathwayPDGFD;KLK1B4;NRAS;Kitl;RAB5B;PLA2G2F;GNB3;GNG2;SHC1
Rap signaling pathwayANGPT4;LAT;SRC;PRKCA;PIK3CB;ARAP3;MAP2K3;FGF1;ITGB2L
Calcium signaling pathwayATP2B3B;PPIFB;CALM2;PPP3R1;CYSLTR2;PLCB2;CAMK4;TRHRB;HTR7
Cytokine-cytokine receptor interactionCCL7;IL2RG;TGFB2;CCR1L1;IL20RA;LIFRA;Flt3l;NGFRB;CCL2
Phospholipase D signaling pathwayPIK3R3;AVPR2;DGKD;SYK;AVPR1A;KRAS;PPAP2C;PRKCA;AVPR1B
PIK-Akt signaling pathwayRAC1;TEK;GNB2;IL6;YWHAH;PCK1;GNB4;FGF14;NFKB1
Focal adhesionELK1;COL4A2;COL2A1B;ITGA3B;ITGB8;MLCK2;PDGFRA;PARVG;ITGA5
Gap junctionTUBA1B;GUCY1B3;GRB2;HRAS;DRD2B;MAP2K2B;GNA11A;TUBB1;TUBA3B
Regulation of actin cytoskeletonARPC4L;ACTN2B;SSH3;VIL1;FGFR4;ITGB7;MYL9B;SCIN;FGF14
HTLV-I infectionPIK3CG;PIK3CA;HLA-DRB3;NFATC3;DVL3;PIK3R3;CDC20;CREM;HLA-DRB1
Pathways in cancerVEGFB;TGFB1;WNT6;XIAP;TRAF3;FGFR2;BCL2L1;KIT;IL6
MicroRNAs in cancerRDX;ZEB1;CDC25A;MMP9;TNC;TNR;GRB2;TTC6;FOXP1
GliomaPIK3CG;BRAF;AKT2;CAMK2B;PIK3CD;SHC1;PDGFRA;CALML3;SOS1
Prostate cancerPIK3R3;AKT2;MAP2K1;KRAS;INS1;LEF1;CCNE2;SPRY1;IGF1
MelanomaMAPK1;FGF3;FGF17;FGF21;PIK3R2;FGF5;FGF6;AKT2;FGF13
Central carbon metabolism in cancerHK2;SLC7A5;KRAS;C12orf5;PDHB;PDK1;MET;HKDC1;SLC16A3
Choline metabolism in cancerPIK3CG;SOS1;PDGFB;PIK3R3;MAPK3;CHKB;RAC1;PLCG1;NRAS

PDGFRB has several biochemical functions, for example, ATP binding, phosphatidylinositol 3-kinase binding, platelet activating factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFRB itself. We selected most functions PDGFRB had, and list some proteins which have the same functions with PDGFRB. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCENPE;HELZ2;ACSBG2;KCNJ8;PIP5K2;FLT3;RTCB;P2RX1;IGF1RB
phosphatidylinositol 3-kinase bindingFLT3;CALM2;JAK2;DAB1;INSRA;CALM1;TYRO3;HCST;IRS4
platelet activating factor receptor activityPDGFRL;PTAFR;PDGFRB
platelet-derived growth factor beta-receptor activityPDGFRB;PDGFRL
platelet-derived growth factor bindingPdgfa&Pdgfb;COL1A1;PDGFRB;PDGFB;COL5A1;COL1A2;COL6A1;PDGFRA;PDGFA
platelet-derived growth factor receptor bindingTYMP;FIGF;IL1R1;ITGA5;PDGFA;PDGFD;PDGFRA;LYN;PDGFB
platelet-derived growth factor-activated receptor activity
protein bindingSLC6A4;SMAGP;OAZ2;F11;ZCCHC10;LEO1;BMP4;TMEM93;CLEC1B
protein kinase bindingFAF1;EPHA1;PTPN1;CCNL1;C10orf46;MS4A2;DUSP3;CNPPD1;DBF4B
protein tyrosine kinase activityWEE1;BTK;TNK2;CLK4;SHC1;JAK3;JAK2B;BAZ1B;EK1
receptor bindingCCL15;LAMA4;WNT2BB;PSPN;MIF;PAOX;CD2;PVRL3B;ADAM10
vascular endothelial growth factor bindingKDR;PDGFRA;PDGFRB;NRP1

PDGFRB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFRB here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFRB.

PIK3R1; PTPN11

Research Area

Related articles

Gotlib, J; et al. CME Information: World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management. AMERICAN JOURNAL OF HEMATOLOGY 89:325-337(2014).
Edlund, K; Lindskog, C; et al. CD99 is a novel prognostic stromal marker in non-small cell lung cancer. INTERNATIONAL JOURNAL OF CANCER 131:2264-2273(2012).
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