PDGFRB
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Official Full Name
platelet derived growth factor receptor, beta polypeptide -
Overview
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. -
Synonyms
PDGFRB;platelet derived growth factor receptor, beta polypeptide;beta-type platelet-derived growth factor receptor;CD140B;Beta platelet derived growth factor receptor;Beta-type platelet-derived growth factor receptor;CD 140B;CD140 antigen-like family member B;CD140b antigen;JTK12;OTTHUMP00000160528;PDGF R beta;PDGF-R-beta;PDGFR;PDGFR1;PDGFRB;PGFRB_HUMAN;Platelet derived growth factor receptor beta;Platelet derived growth factor receptor beta polypeptide;PDGF-R-beta;PDGF beta chain;OTTMUSP00000015854;OTTMUSP00000015855;CD140 antigen-like family member B;platelet-derived growth factor receptor beta variant 1;Pdgfr;CD140b;AI528809
Recombinant Proteins
- Human
- Monkey
- Rat
- Rhesus macaque
- Mouse
- Canine
- Cynomolgus
- Zebrafish
- HEK293
- Sf9 Cells
- Human Cells
- CHO
- Mammalian Cells
- NS0
- C-His
- Insect Cells
- E.coli
- His
- GST
- Fc
- Avi
- Non
- Flag
- DDK
- Myc
Involved Pathway
PDGFRB involved in several pathways and played different roles in them. We selected most pathways PDGFRB participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFRB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Central carbon metabolism in cancer | SCO2,HIF1A,MAPK3,PDHB,PIK3R3,PTEN,SLC1A5,RET,HKDC1,KIT |
| Calcium signaling pathway | GRIN1,ATP2A1L,SLC8A3,PRKCBA,ATP2A3,SLC25A31,ERBB3,LHCGR,VDAC3,CHRM3 |
| HTLV-I infection | WNT3A,FZD7,RELB,CCNB2,FOS,FZD9,WNT2,H2-Q10,MSX2,VDAC3 |
| Rap signaling pathway | Kitl,INS,PIK3CB,PRKCB,VASP,INS2,MAP2K6,PDGFB,ID1,CALM4 |
| Prostate Cancer | HSP90B1,RELA,SPRY1,AKT1,SMARCD1,SOS1,CREB3L1,MAPK3,KRAS,PDPK1 |
| Melanoma | FGF10,FGF9,FGF20,FGF14,FGF17,BRAF,FGF7,FGF3,FGF16,TP53 |
| Focal adhesion | SOS1,RAP1AB,COL1A1B,PDGFB,MYL12A,CHAD,PTENA,PDGFRA,RAC3B,ROCK2B |
| MicroRNAs in cancer | BMF,KRAS,PRKCA,ERBB2,EFNA3,UBE2I,CCNE2,SHC4,ABCB1A,SHC1 |
| PIK-Akt signaling pathway | IL7R,MAP2K1,PDGFC,PIK3CA,TNC,IFNA12,FGFR3,LAMB2,IFNA13,ANGPT2 |
Protein Function
PDGFRB has several biochemical functions, for example, ATP binding,phosphatidylinositol 3-kinase binding,platelet activating factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFRB itself. We selected most functions PDGFRB had, and list some proteins which have the same functions with PDGFRB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| platelet-derived growth factor binding | Pdgfa&Pdgfb,COL5A1,PDGFRA,PDGFB,COL6A1,PDGFA,COL3A1,COL4A1,COL2A1,COL1A2 |
| platelet-derived growth factor beta-receptor activity | PDGFRL |
| phosphatidylinositol 3-kinase binding | INSR,IGF1R,FYN,DAB1,CALM3,IRS4,CALM2,HCST,FLT3,JAK2 |
| vascular endothelial growth factor binding | PDGFRA,NRP1,KDR |
| ATP binding | RPS6KA6,EHD3,ABCG1,TGFBR1,OLA1,TNIKB,SUCLA2,MVK,BMPR1A,ORC4 |
| protein tyrosine kinase activity | BMX,KIT,FGFR3,PTK6B,EPHA4B,DYRK4,TYRO3,CSF1RA,MAP2K7,DYRK1B |
| protein kinase binding | DPYSL2,Fert2,BCL2L1,MAVS,EPHA1,CCNL1A,PAK2,XBP1,LAT,TPRKB |
| platelet-derived growth factor receptor binding | LYN,PDGFB,TYMP,PDGFA,PDGFD,PDGFRA,FIGF,VEGFA,PDGFC,IL1R1 |
| protein binding | MSTN,POLI,FAM131B,ADAM33,ATP7B,YES1,HNRNPL,C10orf119,ATF4,KIAA0101 |
Interacting Protein
PDGFRB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFRB here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFRB.
PIK3R1;PTPN11
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References
- Gotlib, J; et al. CME Information: World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management. AMERICAN JOURNAL OF HEMATOLOGY 89:325-337(2014).
- Edlund, K; Lindskog, C; et al. CD99 is a novel prognostic stromal marker in non-small cell lung cancer. INTERNATIONAL JOURNAL OF CANCER 131:2264-2273(2012).
