Recombinant Human PHB protein, T7/His-tagged
Cat.No. : | PHB-181H |
Product Overview : | Recombinant human PHB cDNA (271 aa) fused with T7-His-TEV cleavage site Tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Human |
Tag : | T7/His |
Form : | 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT. |
AA Sequence : | MASMTGGQQMGRGHHHHHHENLYFQ GGEFAAKVFESIGKFGLALAVAGGV VNSALYNVDAGHRAVIFDRFRGVQD IVVGEGTHFLIPWVQKPIIFDCRSR PRNVPVITGSKDLQNVNITLRILFR PVASQLPRIFTSIGEDYDERVLPSI TTEILKSVVARFDAGELITQRELVS RQVSDDLTERAATFGLILDDVSLTH LTFGKEFTEAVEAKQVAQQEAERAR FVVEKAEQQKKAAIISAEGDSKAAE LIANSLATAGDGLIELRKLEAAEDI AYQLSRSRNITYLPAGQSVLLQLPQ |
Purity : | >90% by SDS-PAGE |
Storage : | Keep at -80 centigrade for long term storage. Product is stable at 4 centigrade for at least 7 days. |
Gene Name : | PHB prohibitin [ Homo sapiens ] |
Official Symbol : | PHB |
Synonyms : | PHB; prohibitin; PHB1; |
Gene ID : | 5245 |
mRNA Refseq : | NM_002634 |
Protein Refseq : | NP_002625 |
MIM : | 176705 |
UniProt ID : | P35232 |
Chromosome Location : | 17q21 |
Function : | histone deacetylase binding; protein binding; transcription regulatory region DNA binding; |
Products Types
◆ Recombinant Protein | ||
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Phb-4832M | Recombinant Mouse Phb Protein, Myc/DDK-tagged | +Inquiry |
PHB-2606M | Recombinant Mouse PHB Protein (41-173 aa), His-tagged | +Inquiry |
PHB-4077R | Recombinant Rat PHB Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PHB-3241HCL | Recombinant Human PHB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionPHB proteins play an important role in cell signal transduction. It can act as a regulator of signal transduction pathways, influencing processes such as cell proliferation, differentiation, and apoptosis. The specific mechanism of action needs to be further studied.
The expression level of PHB protein can be detected by immunohistochemistry, western blotting, and real-time PCR. These techniques can detect protein or mRNA levels of PHB proteins in tissues or cells to assess changes in their expression in disease.
PHB proteins are mainly localized in the inner mitochondrial membrane and nucleus. It plays a role in regulating mitochondrial function and structure on the inner mitochondrial membrane and is involved in processes such as gene transcription and DNA damage repair in the nucleus.
PHB proteins have a variety of biological functions. It is involved in mitochondrial biogenesis and regulates mitochondrial number and function, participates in the process of cell proliferation and apoptosis, affects cell growth and death, and also participates in nuclear activities such as gene transcription and DNA damage repair.
Therapeutic strategies for PHB proteins include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against PHB proteins to inhibit their aberrant activity in diseases, or the regulation of PHB protein expression through gene knockout or overexpression techniques.
There is an interaction between PHB protein and other proteins. It can interact with mitochondria-related proteins to regulate mitochondrial function and structure, and can also interact with nucleus-related proteins to participate in processes such as gene transcription and DNA damage repair.
Customer Reviews (3)
Write a reviewThe catalytic activity is amazing, and the mild nature of the mild nature is appreciated for the highly efficient catalysis achieved under mild conditions.
We like the purity and precision of their products, and the results are accurate and reliable.
Their protein production process is strictly controlled, and the quality of products is guaranteed.
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