| Description : |
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
184.5 kDa |
| AA Sequence : |
MDSEIGCLIRFYAGKPHSTGSSERI QLSGMYNVRKGKMQLPVNRWTRRQV ILCGTCLIVSSVKDSLTGKMHVLPL IGGKVEEVKKHQHCLAFSSSGPQSQ TYYICFDTFTEYLRWLRQVSKVASQ RISSVDLSCCSLEHLPANLFYSQDL THLNLKQNFLRQNPSLPAARGLNEL QRFTKLKSLNLSNNHLGDFPLAVCS IPTLAELNVSCNALRSVPAAVGVMH NLQTFLLDGNFLQSLPAELENMKQL SYLGLSFNEFTDIPEVLEKLTAVDK LCMSGNCVETLRLQALRKMPHIKHV DLRLNVIRKLIADEVDFLQHVTQLD LRDNKLGDLDAMIFNNIEVLHCERN QLVTLDICGYFLKALYASSNELVQL DVYPVPNYLSYMDVSRNRLENVPEW VCESRKLEVLDIGHNQICELPARLF CNSSLRKLLAGHNQLARLPERLERT SVEVLDVQHNQLLELPPNLLMKADS LRFLNASANKLESLPPATLSEETNS ILQELYLTNNSLTDKCVPLLTGHPH LKILHMAYNRLQSFPASKMAKLEEL EEIDLSGNKLKAIPTTIMNCRRMHT VIAHSNCIEVFPEVMQLPEIKCVDL SCNELSEVTLPENLPPKLQELDLTG NPRLVLDHKTLELLNNIRCFKIDQP STGDASGAPAVWSHGYTEASGVKNK LCVAALSVNNFCDNREALYGVFDGD RNVEVPYLLQCTMSDILAEELQKTK NEEEYMVNTFIVMQRKLGTAGQKLG GAAVLCHIKHDPVDPGGSFTLTSAN VGKCQTVLCRNGKPLPLSRSYIMSC EEELKRIKQHKAIITEDGKVNGVTE STRILGYTFLHPSVVPRPHVQSVLL TPQDEFFILGSKGLWDSLSVEEAVE AVRNVPDALAAAKKLCTLAQSYGCH DSISAVVVQLSVTEDSFCCCELSAG GAVPPPSPGIFPPSVNMVIKDRPSD GLGVPSSSSGMASEISSELSTSEMS SEVGSTASDEPPPGALSENSPAYPS EQRCMLHPICLSNSFQRQLSSATFS SAFSDNGLDSDDEEPIEGVFTNGSR VEVEVDIHCSRAKEKEKQQHLLQVP AEASDEGIVISANEDEPGLPRKADF SAVGTIGRRRANGSVAPQERSHNVI EVATDAPLRKPGGYFAAPAQPDPDD QFIIPPELEEEVKEIMKHHQEQQQQ QQPPPPPQLQPQLPRHYQLDQLPDY YDTPLTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
