Recombinant Human PHLPP1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human PHLPP1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : PHLPP1-5157H
Product Overview : PHLPP1 MS Standard C13 and N15-labeled recombinant protein (NP_919431) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 184.5 kDa
AA Sequence : MDSEIGCLIR FYAGKPHSTG SSERIQLSGM YNVRKGKMQL PVNRWTRRQV ILCGTCLIVS SVKDSLTGKM HVLPLIGGKV EEVKKHQHCL AFSSSGPQSQ TYYICFDTFT EYLRWLRQVS KVASQRISSV DLSCCSLEHL PANLFYSQDL THLNLKQNFL RQNPSLPAAR GLNELQRFTK LKSLNLSNNH LGDFPLAVCS IPTLAELNVS CNALRSVPAA VGVMHNLQTF LLDGNFLQSL PAELENMKQL SYLGLSFNEF TDIPEVLEKL TAVDKLCMSG NCVETLRLQA LRKMPHIKHV DLRLNVIRKL IADEVDFLQH VTQLDLRDNK LGDLDAMIFN NIEVLHCERN QLVTLDICGY FLKALYASSN ELVQLDVYPV PNYLSYMDVS RNRLENVPEW VCESRKLEVL DIGHNQICEL PARLFCNSSL RKLLAGHNQL ARLPERLERT SVEVLDVQHN QLLELPPNLL MKADSLRFLN ASANKLESLP PATLSEETNS ILQELYLTNN SLTDKCVPLL TGHPHLKILH MAYNRLQSFP ASKMAKLEEL EEIDLSGNKL KAIPTTIMNC RRMHTVIAHS NCIEVFPEVM QLPEIKCVDL SCNELSEVTL PENLPPKLQE LDLTGNPRLV LDHKTLELLN NIRCFKIDQP STGDASGAPA VWSHGYTEAS GVKNKLCVAA LSVNNFCDNR EALYGVFDGD RNVEVPYLLQ CTMSDILAEE LQKTKNEEEY MVNTFIVMQR KLGTAGQKLG GAAVLCHIKH DPVDPGGSFT LTSANVGKCQ TVLCRNGKPL PLSRSYIMSC EEELKRIKQH KAIITEDGKV NGVTESTRIL GYTFLHPSVV PRPHVQSVLL TPQDEFFILG SKGLWDSLSV EEAVEAVRNV PDALAAAKKL CTLAQSYGCH DSISAVVVQL SVTEDSFCCC ELSAGGAVPP PSPGIFPPSV NMVIKDRPSD GLGVPSSSSG MASEISSELS TSEMSSEVGS TASDEPPPGA LSENSPAYPS EQRCMLHPIC LSNSFQRQLS SATFSSAFSD NGLDSDDEEP IEGVFTNGSR VEVEVDIHCS RAKEKEKQQH LLQVPAEASD EGIVISANED EPGLPRKADF SAVGTIGRRR ANGSVAPQER SHNVIEVATD APLRKPGGYF AAPAQPDPDD QFIIPPELEE EVKEIMKHHQ EQQQQQQPPP PPQLQPQLPR HYQLDQLPDY YDTPLTRTRP LEQKLISEED LAANDILDYK DDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 [ Homo sapiens (human) ]
Official Symbol : PHLPP1
Synonyms : PHLPP1; PH domain and leucine rich repeat protein phosphatase 1; PH domain and leucine rich repeat protein phosphatase, PHLPP, pleckstrin homology domain containing, family E (with leucine rich repeats) member 1, PLEKHE1; PH domain leucine-rich repeat-containing protein phosphatase 1; KIAA0606; SCOP; SCN circadian oscillatory protein; PH domain-containing family E member 1; suprachiasmatic nucleus circadian oscillatory protein; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; PHLPP; PLEKHE1; MGC161555;
Gene ID : 23239
mRNA Refseq : NM_194449
Protein Refseq : NP_919431
MIM : 609396
UniProt ID : O60346

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