Recombinant Human PIN1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human PIN1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : PIN1-6628H
Product Overview : PIN1 MS Standard C13 and N15-labeled recombinant protein (NP_006212) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 18.2 kDa
AA Sequence : MADEEKLPPG WEKRMSRSSG RVYYFNHITN ASQWERPSGN SSSGGKNGQG EPARVRCSHL LVKHSQSRRP SSWRQEKITR TKEEALELIN GYIQKIKSGE EDFESLASQF SDCSSAKARG DLGAFSRGQM QKPFEDASFA LRTGEMSGPV FTDSGIHIIL RTETRTRPLE QKLISEEDLA ANDILDYKDD DDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [ Homo sapiens (human) ]
Official Symbol : PIN1
Synonyms : PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1; protein (peptidyl prolyl cis/trans isomerase) NIMA interacting 1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; dod; PPIase Pin1; rotamase Pin1; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; DOD; UBL5; FLJ40239; FLJ77628; MGC10717;
Gene ID : 5300
mRNA Refseq : NM_006221
Protein Refseq : NP_006212
MIM : 601052
UniProt ID : Q13526

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