| Description : |
The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
117.5 kDa |
| AA Sequence : |
MWRCGGRQGLCVLRRLSGGHAHHRA WRWNSNRACERALQYKLGDKIHGFT VNQVTSVPELFLTAVKLTHDDTGAR YLHLAREDTNNLFSVQFRTTPMDST GVPHILEHTVLCGSQKYPCRDPFFK MLNRSLSTFMNAFTASDYTVYPFST QNPKDFQNLLSVYLDATFFPCLREL DFWQEGWRLEHENPSDPQTPLVFKG VVFNEMKGAFTDNERIFSQHLQNRL LPDHTYSVVSGGDPLCIPELTWEQL KQFHATHYHPSNARFFTYGNFPLEQ HLKQIHEEALSKFQKIEPSTVVPAQ TPWDKPREFQITCGPDSFATDPSKQ TTVSVSFLLPDITDTFEAFTLSLLS SLLTSGPNSPFYKALIESGLGTDFS PDVGYNGYTREAYFSVGLQGIVEKD IETVRSLIDRTIDEVVEKGFEDDRI EALLHKIEIQMKHQSTSFGLMLTSY IASCWNHDGDPVELLKLGNQLAKFR QCLQENPKFLQEKVKQYFKNNQHKL TLSMRPDDKYHEKQAQVEATKLKQK VEALSPGDRQQIYEKGLELRSQQSK PQDASCLPALKVSDIEPTIPVTELD VVLTAGDIPVQYCAQPTNGMVYFRA FSSLNTLPEELRPYVPLFCSVLTKL GCGLLDYREQAQQIELKTGGMSASP HVLPDDSHMDTYEQGVLFSSLCLDR NLPDMMQLWSEIFNNPCFEEEEHFK VLVKMTAQELANGIPDSGHLYASIR AGRTLTPAGDLQETFSGMDQVRLMK RIAEMTDIKPILRKLPRIKKHLLNG DNMRCSVNATPQQMPQTEKAVEDFL RSIGRSKKERRPVRPHTVEKPVPSS SGGDAHVPHGSQVIRKLVMEPTFKP WQMKTHFLMPFPVNYVGECIRTVPY TDPDHASFEILARLMTAKFLHTEIR EKGGAYGGGAKLSHNGIFTLYSYRD PNTIETLQSFGKAVDWAKSGKFTQQ DIDEAKLSVFSTVDAPVAPSDKGMD HFLYGLSDEMKQAHREQLFAVSHDK LLAVSDRYLGTGKSTHGLAILGPEN PKIAKDPSWIIRTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
