| Species : |
Human |
| Source : |
HEK293 |
| Tag : |
His |
| Protein Length : |
20-1197aa |
| Description : |
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. |
| Tag : |
C-His |
| Molecular Mass : |
130.8 kDa |
| Endotoxin : |
Less than 1.0 EU/μg by the LAL method. |
| Purity : |
>95% as determined by SDS-PAGE. |
| Storage : |
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Storage Buffer : |
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol. |
| Reconstitution : |
Reconstitute at 250 μg/mL in sterile water. |
