Recombinant Human PLG protein, GST-tagged

• Cat.No.: PLG-9029H
• Product Overview: Recombinant Human PLG(1 a.a. - 810 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 117 kDa
• AA Sequence: MEHKEVVLLLLLFLKSGQGEPLDDY VNTQGASLFSVTKKQLGAGSIEECA AKCEEDEEFTCRAFQYHSKEQQCVI MAENRKSSIIIRMRDVVLFEKKVYL SECKTGNGKNYRGTMSKTKNGITCQ KWSSTSPHRPRFSPATHPSEGLEEN YCRNPDNDPQGPWCYTTDPEKRYDY CDILECEEECMHCSGENYDGKISKT MSGLECQAWDSQSPHAHGYIPSKFP NKNLKKNYCRNPDRELRPWCFTTDP NKRWELCDIPRCTTPPPSSGPTYQC LKGTGENYRGNVAVTVSGHTCQHWS AQTPHTHNRTPENFPCKNLDENYCR NPDGKRAPWCHTTNSQVRWEYCKIP SCDSSPVSTEQLAPTAPPELTPVVQ DCYHGDGQSYRGTSSTTTTGKKCQS WSSMTPHRHQKTPENYPNAGLTMNY CRNPDADKGPWCFTTDPSVRWEYCN LKKCSGTEASVVAPPPVVLLPDVET PSEEDCMFGNGKGYRGKRATTVTGT PCQDWAAQEPHRHSIFTPETNPRAG LEKNYCRNPDGDVGGPWCYTTNPRK LYDYCDVPQCAAPSFDCGKPQVEPK KCPGRVVGGCVAHPHSWPWQVSLRT RFGMHFCGGTLISPEWVLTAAHCLE KSPRPSSYKVILGAHQEVNLEPHVQ EIEVSRLFLEPTRKDIALLKLSSPA VITDKVIPACLPSPNYVVADRTECF ITGWGETQGTFGAGLLKEAQLPVIE NKVCNRYEFLNGRVQSTELCAGHLA GGTDSCQGDSGGPLVCFEKDKYILQ GVTSWGLGCARPNKPGVYVRVSRFV TWIEGVMRNN
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: PLG plasminogen [ Homo sapiens ]
• Official Symbol: PLG
• Synonyms: PLG; plasminogen; plasmin; DKFZp779M0222
• Gene ID: 5340
• mRNA Refseq: NM_000301
• Protein Refseq: NP_000292
• MIM: 173350
• UniProt ID: P00747
• Chromosome Location: 6q26
• Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Degradation of the extracellular matrix, organism-specific biosystem
• Function: apolipoprotein binding; cell surface binding; peptidase activity; protein binding; protein domain specific binding; serine-type endopeptidase activity