Recombinant Human PLK2

• Cat.No.: PLK2-31029TH
• Product Overview: Recombinant full length Human PLK2 protein with a N terminal proprietary tag. Predicted molecular weight 106 kDa.

Specification

• Description: The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Protein length: 685 amino acids
• Molecular Weight: 106.000kDa inclusive of tags
• Source: Baculovirus infected sf9 cells
• Biological activity: Specific actvity is 13 nmol/min/mg.
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.Contains 2 POLO box domains.Contains 1 protein kinase domain.

Gene Information

• Gene Name: PLK2 polo-like kinase 2 [ Homo sapiens ]
• Official Symbol: PLK2
• Synonyms: PLK2; polo-like kinase 2; polo like kinase 2 (Drosophila); serine/threonine-protein kinase PLK2; serum inducible kinase; SNK
• Gene ID: 10769
• mRNA Refseq: NM_001252226
• Protein Refseq: NP_001239155
• MIM: 607023
• Uniprot ID: Q9NYY3
• Chromosome Location: 5q12.1-q13.2
• Pathway: PLK2 and PLK4 events, organism-specific biosystem; Polo-like kinase signaling events in the cell cycle, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein serine/threonine kinase activity; signal transducer activity