Recombinant Human PLOD1 Protein (Gln636-Pro727), N-GST tagged

• Cat.No.: PLOD1-3742H
• Product Overview: Recombinant human PLOD1 (Gln636-Pro727) fused with the N-GST tag was expressed in E. coli.

Specification

• Description: Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: N-GST
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 37.36 kDa
• Protein Length: Gln636-Pro727
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02% NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: PLOD1 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [ Homo sapiens (human) ]
• Official Symbol: PLOD1
• Synonyms: PLOD1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; LH; LH1; LLH; EDS6; PLOD; EDSKCL1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; lysine hydroxylase; lysyl hydroxlase 1; procollagen lysyl hydroxylase 1; procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1; EC 1.14.11.4
• Gene ID: 5351
• mRNA Refseq: NM_000302
• Protein Refseq: NP_000293
• MIM: 153454
• UniProt ID: Q02809