| Description : |
This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
98.6 kDa |
| AA Sequence : |
MDSTKEKCDSYKDDLLLRMGLNDNK AGMEGLDKEKINKIIMEATKGSRFY GNELKKEKQVNQRIENMMQQKAQIT SQQLRKAQLQVDRFAMELEQSRNLS NTIVHIDMDAFYAAVEMRDNPELKD KPIAVGSMSMLSTSNYHARRFGVRA AMPGFIAKRLCPQLIIVPPNFDKYR AVSKEVKEILADYDPNFMAMSLDEA YLNITKHLEERQNWPEDKRRYFIKM GSSVENDNPGKEVNKLSEHERSISP LLFEESPSDVQPPGDPFQVNFEEQN NPQILQNSVVFGTSAQEVVKEIRFR IEQKTTLTASAGIAPNTMLAKVCSD KNKPNGQYQILPNRQAVMDFIKDLP IRKVSGIGKVTEKMLKALGIITCTE LYQQRALLSLLFSETSWHYFLHISL GLGSTHLTRDGERKSMSVERTFSEI NKAEEQYSLCQELCSELAQDLQKER LKGRTVTIKLKNVNFEVKTRASTVS SVVSTAEEIFAIAKELLKTEIDADF PHPLRLRLMGVRISSFPNEEDRKHQ QRSIIGFLQAGNQALSATECTLEKT DKDKFVKPLEMSHKKSFFDKKRSER KWSHQDTFKCEAVNKQSFQTSQPFQ VLKKKMNENLEISENSDDCQILTCP VCFRAQGCISLEALNKHVDECLDGP SISENFKMFSCSHVSATKVNKKENV PASSLCEKQDYEAHPKIKEISSVDC IALVDTIDNSSKAESIDALSNKHSK EECSSLPSKSFNIEHCHQNSSSTVS LENEDVGSFRQEYRQPYLCEVKTGQ ALVCPVCNVEQKTSDLTLFNVHVDV CLNKSFIQELRKDKFNPVNQPKESS RSTGSSSGVQKAVTRTKRPGLMTKY STSKKIKPNNPKHTLDIFFKTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
