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Active Recombinant Human PON1 Protein, His-tagged

Cat.No. : PON1-01H
Product Overview : Recombinant human PON1 (16-355) protein with a His-tag was expressed in HEK293.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7.
Source : HEK293
Species : Human
Tag : His
Form : Liquid
Bio-activity : Specific activity is > 2,500 pmol/min/µg, and is defined as the amount of enzyme that hydrolyze 1pmole of p-nitrophenyl acetate to p-nitrophenol per minute at pH7.5 at 37 centigrade.
Molecular Mass : 39 kDa
Protein length : 16-355
Endotoxin : < 1 EU per 1 µg of protein (determined by LAL method)
Purity : > 90% by SDS-PAGE
Applications : SDS-PAGE, Enzyme Activity
Storage : Stored at +2 centigrade to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 centigrade to -80 centigrade. Avoid repeated freezing and thawing cycles
Concentration : 0.25 mg/ml
Storage Buffer : Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol
Gene Name : PON1 paraoxonase 1 [ Homo sapiens (human) ]
Official Symbol : PON1
Synonyms : PON1; paraoxonase 1; ESA; PON; MVCD5; serum paraoxonase/arylesterase 1; A-esterase 1; K-45; PON 1; aromatic esterase 1; arylesterase 1; arylesterase B-type; esterase A; paraoxonase B-type; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1
Gene ID : 5444
mRNA Refseq : NM_000446
Protein Refseq : NP_000437
MIM : 168820
UniProt ID : P27169

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any genetic tests available to assess PON1 activity? 08/17/2022

Yes, genetic tests can determine an individual's PON1 genotype and predict their enzyme activity.

Can PON1 activity be influenced by genetics? 07/30/2022

Yes, PON1 activity can be influenced by genetic variations, leading to different enzyme levels and activity.

How is PON1 linked to the metabolism of drugs and xenobiotics? 08/20/2019

PON1 can hydrolyze and detoxify certain drugs and environmental toxins, making it important in drug metabolism.

Can PON1 be used to assess an individual's susceptibility to organophosphate toxicity? 02/26/2019

Yes, PON1 activity levels can help predict an individual's susceptibility to organophosphate toxicity.

How is PON1 associated with atherosclerosis and heart disease? 05/04/2017

PON1 protects against atherosclerosis by preventing the oxidation of LDL cholesterol, a key factor in heart disease.

Customer Reviews (3)

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Reviews
02/06/2022

    The manufacturer's team of experts possesses a deep understanding of the PON1 protein and its associated protocols.

    07/20/2020

      This high-quality PON1 protein provides researchers with confidence in obtaining accurate and reliable data during their investigations

      04/27/2019

        In conclusion, using PON1 protein in trials offers distinct advantages for researchers studying cell cycle regulation.

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