Active Recombinant Human PON1 Protein, His-tagged
Cat.No. : | PON1-01H |
Product Overview : | Recombinant human PON1 (16-355) protein with a His-tag was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Liquid |
Bio-activity : | Specific activity is > 2,500 pmol/min/µg, and is defined as the amount of enzyme that hydrolyze 1pmole of p-nitrophenyl acetate to p-nitrophenol per minute at pH7.5 at 37 centigrade. |
Molecular Mass : | 39 kDa |
Protein length : | 16-355 |
Endotoxin : | < 1 EU per 1 µg of protein (determined by LAL method) |
Purity : | > 90% by SDS-PAGE |
Applications : | SDS-PAGE, Enzyme Activity |
Storage : | Stored at +2 centigrade to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 centigrade to -80 centigrade. Avoid repeated freezing and thawing cycles |
Concentration : | 0.25 mg/ml |
Storage Buffer : | Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol |
Gene Name : | PON1 paraoxonase 1 [ Homo sapiens (human) ] |
Official Symbol : | PON1 |
Synonyms : | PON1; paraoxonase 1; ESA; PON; MVCD5; serum paraoxonase/arylesterase 1; A-esterase 1; K-45; PON 1; aromatic esterase 1; arylesterase 1; arylesterase B-type; esterase A; paraoxonase B-type; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1 |
Gene ID : | 5444 |
mRNA Refseq : | NM_000446 |
Protein Refseq : | NP_000437 |
MIM : | 168820 |
UniProt ID : | P27169 |
Products Types
◆ Recombinant Protein | ||
PON1-32H | Active Recombinant Human PON1 Protein, His/Fc-tagged | +Inquiry |
PON1-732H | Recombinant Human PON1 Protein (2-355 aa), GST-tagged | +Inquiry |
PON1-33H | Recombinant Human PON1 Protein, MYC/DDK-tagged | +Inquiry |
PON1-4237R | Recombinant Rat PON1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Pon1-5013M | Recombinant Mouse Pon1 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
PON1-3014HCL | Recombinant Human PON1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1109 | Paraoxonase 1 (PON1) Activity Assay Kit (Fluorometric) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, genetic tests can determine an individual's PON1 genotype and predict their enzyme activity.
Yes, PON1 activity can be influenced by genetic variations, leading to different enzyme levels and activity.
PON1 can hydrolyze and detoxify certain drugs and environmental toxins, making it important in drug metabolism.
Yes, PON1 activity levels can help predict an individual's susceptibility to organophosphate toxicity.
PON1 protects against atherosclerosis by preventing the oxidation of LDL cholesterol, a key factor in heart disease.
Customer Reviews (3)
Write a reviewThe manufacturer's team of experts possesses a deep understanding of the PON1 protein and its associated protocols.
This high-quality PON1 protein provides researchers with confidence in obtaining accurate and reliable data during their investigations
In conclusion, using PON1 protein in trials offers distinct advantages for researchers studying cell cycle regulation.
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