| Description : |
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. |
| Protein length : |
680 amino acids |
| Molecular Weight : |
100.870kDa inclusive of tags |
| Source : |
Wheat germ |
| Biological activity : |
useful for Antibody Production and Protein Array |
| Form : |
Liquid |
| Purity : |
Proprietary Purification |
| Storage buffer : |
pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HClNote: Glutathione is reduced |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
MINMGDSHVDTSSTVSEAVAEEVSL FSMTDMILFSLIVGLLTYWFLFRKK KEEVPEFTKIQTLTSSVRESSFVEK MKKTGRNIIVFYGSQTGTAEEFANR LSKDAHRYGMRGMSADPEEYDLADL SSLPEIDNALVVFCMATYGEGDPTD NAQDFYDWLQETDVDLSGVKFAVFG LGNKTYEHFNAMGKYVDKRLEQLGA QRIFELGLGDDDGNLEEDFITWREQ FWLAVCEHFGVEATGEESSIRQYEL VVHTDIDAAKVYMGEMGRLKSYENQ KPPFDAKNPFLAAVTTNRKLNQGTE RHLMHLELDISDSKIRYESGDHVAV YPANDSALVNQLGKILGADLDVVMS LNNLDEESNKKHPFPCPTSYRTALT YYLDITNPPRTNVLYELAQYASEPS EQELLRKMASSSGEGKELYLSWVVE ARRHILAILQDCPSLRPPIDHLCEL LPRLQARYYSIASSSKVHPNSVHIC AVVVEYETKAGRINKGVATNWLRAK EPVGENGGRALVPMFVRKSQFRLPF KATTPVIMVGPGTGVAPFIGFIQER AWLRQQGKEVGETLLYYGCRRSDED YLYREELAQFHRDGALTQLNVAFSR EQSHKVYVQHLLKQDREHLWKLIEG GAHIYVCGDARNMARDVQNTFYDIV AELGAMEHAQAVDYIKKLMTKGRYS LDVWS |
| Sequence Similarities : |
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.Contains 1 FAD-binding FR-type domain.Contains 1 flavodoxin-like domain. |
