| Description : |
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
77.1 kDa |
| AA Sequence : |
MINMGDSHVDTSSTVSEAVAEEVSL FSMTDMILFSLIVGLLTYWFLFRKK KEEVPEFTKIQTLTSSVRESSFVEK MKKTGRNIIVFYGSQTGTAEEFANR LSKDAHRYGMRGMSADPEEYDLADL SSLPEIDNALVVFCMATYGEGDPTD NAQDFYDWLQETDVDLSGVKFAVFG LGNKTYEHFNAMGKYVDKRLEQLGA QRIFELGLGDDDGNLEEDFITWREQ FWLAVCEHFGVEATGEESSIRQYEL VVHTDIDAAKVYMGEMGRLKSYENQ KPPFDAKNPFLAAVTTNRKLNQGTE RHLMHLELDISDSKIRYESGDHVAV YPANDSALVNQLGKILGADLDVVMS LNNLDEESNKKHPFPCPTSYRTALT YYLDITNPPRTNVLYELAQYASEPS EQELLRKMASSSGEGKELYLSWVVE ARRHILAILQDCPSLRPPIDHLCEL LPRLQARYYSIASSSKVHPNSVHIC AVVVEYETKAGRINKGVATNWLRAK EPVGENGGRALVPMFVRKSQFRLPF KATTPVIMVGPGTGVAPFIGFIQER AWLRQQGKEVGETLLYYGCRRSDED YLYREELAQFHRDGALTQLNVAFSR EQSHKVYVQHLLKQDREHLWKLIEG GAHIYVCGDARNMARDVQNTFYDIV AELGAMEHAQAVDYIKKLMTKGRYS LDVWSTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
