Description : |
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
71.3 kDa |
AA Sequence : |
MSLVPATNYIYTPLNQLKGGTIVNV YGVVKFFKPPYLSKGTDYCSVVTIV DQTNVKLTCLLFSGNYEALPIIYKN GDIVRFHRLKIQVYKKETQGITSSG FASLTFEGTLGAPIIPRTSSKYFNF TTEDHKMVEALRVWASTHMSPSWTL LKLCDVQPMQYFDLTCQLLGKAEVD GASFLLKVWDGTRTPFPSWRVLIQD LVLEGDLSHIHRLQNLTIDILVYDN HVHVARSLKVGSFLRIYSLHTKLQS MNSENQTMLSLEFHLHGGTSYGRGI RVLPESNSDVDQLKKDLESANLTAN QHSDVICQSEPDDSFPSSGSVSLYE VERCQQLSATILTDHQYLERTPLCA ILKQKAPQQYRIRAKLRSYKPRRLF QSVKLHCPKCHLLQEVPHEGDLDII FQDGATKTPVVKLQNTSLYDSKIWT TKNQKGRKVAVHFVKNNGILPLSNE CLLLIEGGTLSEICKLSNKFNSVIP VRSGHEDLELLDLSAPFLIQGTIHH YGCKQCSSLRSIQNLNSLVDKTSWI PSSVAEALGIVPLQYVFVMTFTLDD GTGVLEAYLMDSDKFFQIPASEVLM DDDLQKSVDMIMDMFCPPGIKIDAY PWLECFIKSYNVTNGTDNQICYQIF DTTVAEDVITRTRPLEQKLISEEDL AANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |