Recombinant Human PPARA protein, His&Myc-tagged

• Cat.No.: PPARA-2251H
• Product Overview: Recombinant Human PPARA protein(Q07869)(1-468aa), fused to N-terminal His tag and C-terminal Myc tag, was expressed in Insect Cell.

Specification

• Source: Insect Cell
• Species: Human
• Tag: His&Myc
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 56.2 kDa
• Protein length: 1-468aa
• AA Sequence: MVDTESPLCPLSPLEAGDLESPLSE EFLQEMGNIQEISQSIGEDSSGSFG FTEYQYLGSCPGSDGSVITDTLSPA SSPSSVTYPVVPGSVDESPSGALNI ECRICGDKASGYHYGVHACEGCKGF FRRTIRLKLVYDKCDRSCKIQKKNR NKCQYCRFHKCLSVGMSHNAIRFGR MPRSEKAKLKAEILTCEHDIEDSET ADLKSLAKRIYEAYLKNFNMNKVKA RVILSGKASNNPPFVIHDMETLCMA EKTLVAKLVANGIQNKEAEVRIFHC CQCTSVETVTELTEFAKAIPGFANL DLNDQVTLLKYGVYEAIFAMLSSVM NKDGMLVAYGNGFITREFLKSLRKP FCDIMEPKFDFAMKFNALELDDSDI SLFVAAIICCGDRPGLLNVGHIEKM QEGIVHVLRLHLQSNHPDDIFLFPK LLQKMADLRQLVTEHAQLVQIIKKT ESDAALHPLLQEIYRDMY
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Gene Information

• Gene Name: PPARA peroxisome proliferator-activated receptor alpha [ Homo sapiens ]
• Official Symbol: PPARA
• Synonyms: PPARA; peroxisome proliferator-activated receptor alpha; peroxisome proliferative activated receptor, alpha , PPAR; hPPAR; NR1C1; PPAR-alpha; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; PPAR; PPARalpha; MGC2237; MGC2452
• Gene ID: 5465
• mRNA Refseq: NM_001001928
• Protein Refseq: NP_001001928
• UniProt ID: Q07869

Reviews

03/21/2018

Their expertise and responsiveness exemplify their dedication to assisting customers, offering solutions and guidance whenever challenges arise.

01/17/2018

The combination of the protein's exceptional characteristics and the manufacturer's outstanding technical assistance equips me with the necessary resources to overcome potential hurdles and achieve groundbreaking results.

02/26/2017

Its impressive purity and functional properties make it an ideal choice for my research, ensuring precise and accurate results.

Q&As

How does PPARA affect lipid metabolism?

PPARA enhances the breakdown of fatty acids and promotes their oxidation, thereby playing a key role in lipid metabolism.

Are there any PPARA-targeted drugs available?

Yes, fibrates are a class of drugs that act as PPARA agonists and are used to treat conditions such as hyperlipidemia.

Can PPARA activation be beneficial in neurodegenerative diseases?

Some research suggests that PPARA activation may have neuroprotective effects and could be explored as a therapeutic avenue for neurodegenerative diseases.

In what tissues is PPARA predominantly expressed?

PPARA is predominantly expressed in tissues with high energy expenditure, such as the liver, heart, and skeletal muscle.

Can PPARA activation be targeted for treating dyslipidemia?

Yes, PPARA agonists have been investigated as potential therapeutic agents for managing dyslipidemia by promoting lipid metabolism.