Recombinant Human PPARD Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PPARD-6538H
• Product Overview: PPARD MS Standard C13 and N15-labeled recombinant protein (NP_006229) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 49.7 kDa
• AA Sequence: MEQPQEEAPEVREEEEKEEVAEAEG APELNGGPQHALPSSSYTDLSRSSS PPSLLDQLQMGCDGASCGSLNMECR VCGDKASGFHYGVHACEGCKGFFRR TIRMKLEYEKCERSCKIQKKNRNKC QYCRFQKCLALGMSHNAIRFGRMPE AEKRKLVAGLTANEGSQYNPQVADL KAFSKHIYNAYLKNFNMTKKKARSI LTGKASHTAPFVIHDIETLWQAEKG LVWKQLVNGLPPYKEISVHVFYRCQ CTTVETVRELTEFAKSIPSFSSLFL NDQVTLLKYGVHEAIFAMLASIVNK DGLLVANGSGFVTREFLRSLRKPFS DIIEPKFEFAVKFNALELDDSDLAL FIAAIILCGDRPGLMNVPRVEAIQD TILRALEFHLQANHPDAQYLFPKLL QKMADLRQLVTEHAQMMQRIKKTET ETSLHPLLQEIYKDMYTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PPARD peroxisome proliferator-activated receptor delta [ Homo sapiens (human) ]
• Official Symbol: PPARD
• Synonyms: PPARD; peroxisome proliferator-activated receptor delta; peroxisome proliferative activated receptor, delta; FAAR; NR1C2; NUC1; NUCII; PPAR-beta; PPAR-delta; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferator-activated receptor beta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; NUCI; PPARB; MGC3931
• Gene ID: 5467
• mRNA Refseq: NM_006238
• Protein Refseq: NP_006229
• MIM: 600409
• UniProt ID: Q03181