| Description : |
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
113 kDa |
| AA Sequence : |
MMSDASDMLAAALEQMDGIIAGSKA LEYSNGIFDCQSPTSPFMGSLRALH LVEDLRGLLEMMETDEKEGLRCQIP DSTAETLVEWLQSQMTNGHLPGNGD VYQERLARLENDKESLVLQVSVLTD QVEAQGEKIRDLEFCLEEHREKLNA TEEMLQQELLSRTSLETQKLDLMAE ISNLKLKLTAVEKDRLDYEDKFRDT EGLIQEINDLRLKVSEMDSERLQYE KKLKSTKDELASLKEQLEEKESEVK RLQEKLVCKMKGEGVEIVDRDENFK KKLKEKNIEVQKMKKAVESLMAANE EKDRKIEDLRQCLNRYKKMQDTVVL AQGKKGKDGEYEELLNSSSISSLLD AQGFSDLEKSPSPTPVMGSPSCDPF NTSVPEEFHTTILQVSIPSLLPATV SMETSEKSKLTPKPETSFEENDGNI ILGATVDTQLCDKLLTSSLQKSSSL GNLKKETSDGEKETIQKTSEDRAPA ESRPFGTLPPRPPGQDTSMDDNPFG TRKVRSSFGRGFFKIKSNKRTASAP NLDRKRSASAPTLAETEKETAEHLD LAGASSRPKDSQRNSPFQIPPPSPD SKKKSRGIMKLFGKLRRSQSTTFNP DDMSEPEFKRGGTRATAGPRLGWSR DLGQSNSDLDMPFAKWTKEQVCNWL MEQGLGSYLNSGKHWIASGQTLLQA SQQDLEKELGIKHSLHRKKLQLALQ ALGSEEETNHGKLDFNWVTRWLDDI GLPQYKTQFDEGRVDGRMLHYMTVD DLLSLKVVSVLHHLSIKRAIQVLRI NNFEPNCLRRRPSDENTIAPSEVQK WTNHRVMEWLRSVDLAEYAPNLRGS GVHGGLMVLEPRFNVETMAQLLNIP PNKTLLRRHLATHFNLLIGAEAQHQ KRDAMELPDYVLLTATAKVKPKKLA FSNFGNLRKKKQEDGEEYVCPMELG QASGSASKKGFKPGLDMHLYEEDDL DRLEQMEDSEGTVRQIGAFSEGINN LTHMLKEDDMFKDFAARSPSASITD EDSNVTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
