Recombinant Human PRDM9 Protein, His-tagged
| Cat.No. : | PRDM9-127H |
| Product Overview : | Recombinant N-terminal His-tagged human PRDM9 protein (2-511) expressed in E. coli. |
- Specification
- Gene Information
- Related Products
| Description : | The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His |
| Molecular Mass : | 60.5 kDa |
| Protein length : | 2-511 |
| Stability : | ≥ 1 year |
| Storage : | At -80 centigrade. |
| Storage Buffer : | 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol |
| Gene Name : | PRDM9 PR/SET domain 9 [ Homo sapiens (human) ] |
| Official Symbol : | PRDM9 |
| Synonyms : | PRDM9; PR/SET domain 9; PFM6; KMT8B; MSBP3; ZNF899; MEISETZ; histone-lysine N-methyltransferase PRDM9; PR domain 9; PR domain containing 9; PR domain zinc finger protein 9; [histone H3]-lysine36 N-trimethyltransferase PRDM9; [histone H3]-lysine4 N-trimethyltransferase PRDM9; [histone H3]-lysine9 N-trimethyltransferase PRDM9; [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9; [histone H4]-lysine20 N-methyltransferase PRDM9; histone methyl transferase; minisatellite binding protein 3 (115kD); protein-lysine N-methyltransferase PRDM9; EC 2.1.1.354; EC 2.1.1.355; EC 2.1.1.359; EC 2.1.1.361; EC 2.1.1.362 |
| Gene ID : | 56979 |
| mRNA Refseq : | NM_020227 |
| Protein Refseq : | NP_064612 |
| MIM : | 609760 |
| UniProt ID : | Q9NQV7 |
Products Types
| ◆ Recombinant Protein | ||
| PRDM9-024H | Recombinant Human PRDM9 Protein, His-tagged | +Inquiry |
| PRDM9-4316R | Recombinant Rat PRDM9 Protein, His (Fc)-Avi-tagged | +Inquiry |
| PRDM9-173H | Recombinant Human PRDM9 Protein, GST-tagged | +Inquiry |
| PRDM9-4657R | Recombinant Rat PRDM9 Protein | +Inquiry |
| PRDM9-11145Z | Recombinant Zebrafish PRDM9 | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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