Recombinant Human prepronociceptin, His-tagged

• Cat.No.: PNOC-554H
• Product Overview: PNOC, 20-176aa, Human His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 20-176 a.a.
• Description: Prepronociceptin, also known as PNOC, is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. This protein may be involved in neuronal differentiation and development. Recombinant human PNOC protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• Molecular Mass: 20.6 kDa (180aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSSCQRDCL TCQEKLHPAL DSFDLEVCIL ECEEKVFPSP LWTPCTKVMA RSSWQLSPAA PEHVAAALYQ PRASEMQHLR RMPRVRSLFQ EQEEPEPGME EAGEMEQKQL QKRFGGFTGA RKSARKLANQ KRFSEFMRQY LVLSMQSSQR RRTLHQNGNV
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: PNOC prepronociceptin [ Homo sapiens ]
• Official Symbol: PNOC
• Synonyms: PNOC; prepronociceptin; nocistatin; PPNOC; nociceptin; propronociceptin
• Gene ID: 5368
• mRNA Refseq: NM_006228
• Protein Refseq: NP_006219
• MIM: 601459
• UniProt ID: Q13519
• Chromosome Location: 8p21
• Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem
• Function: neuropeptide hormone activity; opioid peptide activity