| Description : |
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
77 kDa |
| AA Sequence : |
MADPAAGPPPSEGEESTVRFARKGA LRQKNVHEVKNHKFTARFFKQPTFC SHCTDFIWGFGKQGFQCQVCCFVVH KRCHEFVTFSCPGADKGPASDDPRS KHKFKIHTYSSPTFCDHCGSLLYGL IHQGMKCDTCMMNVHKRCVMNVPSL CGTDHTERRGRIYIQAHIDRDVLIV LVRDAKNLVPMDPNGLSDPYVKLKL IPDPKSESKQKTKTIKCSLNPEWNE TFRFQLKESDKDRRLSVEIWDWDLT SRNDFMGSLSFGISELQKASVDGWF KLLSQEEGEYFNVPVPPEGSEANEE LRQKFERAKISQGTKVPEEKTTNTV SKFDNNGNRDRMKLTDFNFLMVLGK GSFGKVMLSERKGTDELYAVKILKK DVVIQDDDVECTMVEKRVLALPGKP PFLTQLHSCFQTMDRLYFVMEYVNG GDLMYHIQQVGRFKEPHAVFYAAEI AIGLFFLQSKGIIYRDLKLDNVMLD SEGHIKIADFGMCKENIWDGVTTKT FCGTPDYIAPEIIAYQPYGKSVDWW AFGVLLYEMLAGQAPFEGEDEDELF QSIMEHNVAYPKSMSKEAVAICKGL MTKHPGKRLGCGPEGERDIKEHAFF RYIDWEKLERKEIQPPYKPKACGRN AENFDRFFTRHPPVLTPPDQEVIRN IDQSEFEGFSFVNSEFLKPEVKSTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
