Recombinant Human proline-rich nuclear receptor coactivator 2, His-tagged

• Cat.No.: PNRC2-231H
• Product Overview: PNRC2, 1-139aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-139 a.a.
• Description: PNRC2 is involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. This protein may act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. It is required for UPF1/RENT1 localization to the P-body and also acts as a nuclear receptor coactivator. PNRC2 may play a role in controlling the energy balance between energy storage and energy expenditure. Recombinant human PNCR2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
• Molecular Mass: 18.0kDa (162aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMGGGERY NIPAPQSRNV SKNQQQLNRQ KTKEQNSQMK IVHKKKERGH GYNSSAAAWQ AMQNGGKNKN FPNNQSWNSS LSGPRLLFKS QANQNYAGAK FSEPPSPSVL PKPPSHWVPV SFNPSDKEIM TFQLKTLLKV QV
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: PNRC2 proline-rich nuclear receptor coactivator 2 [ Homo sapiens ]
• Official Symbol: PNRC2
• Synonyms: PNRC2; proline-rich nuclear receptor coactivator 2; FLJ20312; MGC99541
• Gene ID: 55629
• mRNA Refseq: NM_017761
• Protein Refseq: NP_060231
• MIM: 611882
• UniProt ID: Q9NPJ4
• Chromosome Location: 1p36.11
• Function: protein binding