Recombinant Human Promyelocytic Leukemia, GST-tagged

• Cat.No.: PML-2375H
• Product Overview: Recombinant human PML SUMOylation site peptide produced inE.colias a GST-tagged protein, 28.459 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: A peptide representing the sequence of the primary PML SUMOylation site (Lys-490) and its surrounding amino acid residues (485-495) acts as a target protein for in vitro SUMOylation and has utility as a substrate for SUMO chain formation. Suggested uses :Substrate for in vitro SUMOylation reactions, Investigation of SUMO conjugation pathway and SUMO chain formation, GST pull down of SUMO modified PML species.
• Source/Host: E.coli.
• Purity: ≥95% (SDS-PAGE).
• Long Term Storage: -80°C.

Gene Information

• Gene Name: PML promyelocytic leukemia [ Homo sapiens ]
• Synonyms: promyelocytic leukemia; MYL; RNF71; PP8675; TRIM19; PML; probable transcription factor PML; RING finger protein 71; promyelocytic leukemia protein; tripartite motif protein TRIM19; promyelocytic leukemia, inducer of; tripartite motif-containing protein 19; Tripartite motif-containing protein 19; RING finger protein 71
• Gene ID: 5371
• mRNA Refseq: NM_002675
• Protein Refseq: NP_002666
• MIM: 102578
• UniProt ID: P29590
• Chromosome Location: 15q22
• Pathway: Acute myeloid leukemia; Endocytosis; Pathways in cancer; Ubiquitin mediated proteolysis
• Function: protein homodimerization activity; transcription regulator activity; ubiquitin protein ligase binding; DNA binding; SMAD binding; metal ion binding; protein binding; zinc ion binding