Recombinant Human PRSS22, His-tagged

• Cat.No.: PRSS22-7980H
• Product Overview: Recombinant Human BrainSpecific Serine Protease 4/BSSP4 produced by transfected human cells is a secreted protein with sequence(Ala33Ser317) of Human BSSP4 Tryptase fused with a polyhistidine tag at the Cterminus.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Description: BrainSpecific Serine Protease 4 (BSSP4) is a serine protease that preferentially cleaves the synthetic substrate HDLeuThrArgpNA compared to tosylGlyProArgpNA. BSSP4 is expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and fetal lung, but scarce in adult lung and expressed at low levels in placenta, pancreas, prostate and thyroid gland. BSSP4 belongs to the peptidase S1 family and related to trypsin, referentially hydrolyzing substrates after arginine and lysine residues. However, BSSP4 is less susceptible to inhibition by common trypsin inhibitors such as aprotinin, alpha1antitrypsin and secretory leukocyte protease inhibitor. BSSP4 efficiently converts prourokinase type plasminogen activator to its mature, active form.
• Form: Supplied as a 0.2 μM filtered solution of 20mM HAcNaAc, 150mM NaCl, 10% Glycerol, pH 4.5
• AA Sequence: ARIPVPPACG KPQQLNRVVG GEDSTDSEWP WIVSIQKNGT HHCAGSLLTS RWVITAAHCF KDNLNKPYL FSVLLGAWQL GNPGSRSQKV GVAWVEPHPV YSWKEGACAD IALVRLERSI Q FSERVLPI CLPDASIHLP PNTHCWISGW GSIQDGVPLP HPQTLQKLKV PIIDSEVCSH LY WRGAGQG PITEDMLCAG YLEGERDACL GDSGGPLMCQ VDGAWLLAGI ISWGEGCAER NRP GVYISL SAHRSWVEKI
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Store at less than 20°C. stable for 6 months after receipt.Please minimize freezethaw cycles.

Gene Information

• Gene Name: PRSS22 protease, serine, 22 [ Homo sapiens ]
• Official Symbol: PRSS22
• Synonyms: PRSS22; protease, serine, 22; brain-specific serine protease 4; brain specific serine protease 4; BSSP 4; hBSSP 4; SP001LA; prosemin; tryptase epsilon; serine protease 22; serine protease 26; protease, serine S1 family member 22; BSSP-4; hBSSP-4; MGC9599
• Gene ID: 64063
• mRNA Refseq: NM_022119
• Protein Refseq: NP_071402
• MIM: 609343
• UniProt ID: Q9GZN4
• Chromosome Location: 16p13.3
• Function: peptidase activity; serine-type endopeptidase activity