| Description : |
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
52.5 kDa |
| AA Sequence : |
MTELPAPLSYFQNAQMSEDNHLSNT VRSQNDNRERQEHNDRRSLGHPEPL SNGRPQGNSRQVVEQDEEEDEELTL KYGAKHVIMLFVPVTLCMVVVVATI KSVSFYTRKDGQLIYTPFTEDTETV GQRALHSILNAAIMISVIVVMTILL VVLYKYRCYKVIHAWLIISSLLLLF FFSFIYLGEVFKTYNVAVDYITVAL LIWNFGVVGMISIHWKGPLRLQQAY LIMISALMALVFIKYLPEWTAWLIL AVISVYDLVAVLCPKGPLRMLVETA QERNETLFPALIYSSTMVWLVNMAE GDPEAQRRVSKNSKYNAESTERESQ DTVAENDDGGFSEEWEAQRDSHLGP HRSTPESRAAVQELSSSILAGEDPE ERGVKLGLGDFIFYSVLVGKASATA SGDWNTTIACFVAILIGLCLTLLLL AIFKKALPALPISITFGLVFYFATD YLVQPFMDQLAFHQFYITRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
