|Product Overview:||Recombinant Human PSG6(Gln35-His424) fused with His tag at C-terminal was expressed in HEK293.|
|Description:||Pregnancy-specific glycoprotein 6 (PSG-6), also known as PSG10 and PSGGB is a secreted glycoprotein of the PSG family within the CEA (carcinoembryonic antigen) superfamily. Mature human PSG-6 is a 401 amino acid (aa) protein that consists of four tandem immunoglobulin-like domains followed by a 30 aa C-terminal tail. The N-terminal Ig-like domain contains an Arg-Gly-Asp (RGD) sequence which is a consensus integrin-binding motif found in many adhesion proteins. Alternative splicing generates an additional isoform with a substitution in the C-terminal tail. PSG-6 is predominantly expressed in placenta and more weakly in granulocytes. It induces monocyte production of the cytokines IL-6, IL-10, and TGF-beta 1.|
|Predicted N Terminal:||No results obtained. Gln35 inferred from enzymatic pyroglutamate treatment revealing Val36|
|Form:||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Bio-activity:||Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.9-4.5 μg/mL.|
|Molecular Mass:||Predicted Molecular Mass: 45 kDa
SDS-PAGE: 62-73 kDa, reducing conditions
|Endotoxin:||<0.1 EU per 1 μg of the protein by the LAL method.|
|Purity:||>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.|
|Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
|Reconstitution:||Reconstitute at 500 μg/mL in PBS.|
|Gene Name:||PSG6 pregnancy specific beta-1-glycoprotein 6 [ Homo sapiens ]|
|Synonyms:||PSG6; pregnancy specific beta-1-glycoprotein 6; pregnancy-specific beta-1-glycoprotein 6; PS-beta-G-6; PS-beta-G-10; PS-beta-G-12; pregnancy-specific beta-1-glycoprotein 10; pregnancy-specific beta-1-glycoprotein 12; PSG10; PSBG-6; PSBG-10; PSBG-12;|
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