Recombinant Human PTBP2 protein, His-tagged

• Cat.No.: PTBP2-83H
• Product Overview: Recombinant Human PTBP2, fused with N-His tag, was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 546aa(including fusion tag)
• Description: RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.
• Form: 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH8.0.
• Molecular Mass: 59.4kDa(including fusion tag)
• Applications: WB, ELISA, IP, antibody production, protein array
• Storage: Store at -80centigrade and avoid repeated freeze-thaw cycles

Gene Information

• Gene Name: PTBP2 polypyrimidine tract binding protein 2 [ Homo sapiens ]
• Official Symbol: PTBP2
• Synonyms: PTBP2; polypyrimidine tract binding protein 2; polypyrimidine tract-binding protein 2; brPTB; nPTB; PTB; PTBLP; PTB-like protein; splicing regulator; neurally-enriched homolog of PTB; neural polypyrimidine tract binding protein; neural polypyrimidine tract-binding protein; nPTB5; nPTB6; nPTB7; nPTB8; FLJ34897
• Gene ID: 58155
• mRNA Refseq: NM_021190
• Protein Refseq: NP_067013
• MIM: 608449
• UniProt ID: Q9UKA9
• Chromosome Location: 1p21.3
• Pathway: mRNA processing, organism-specific biosystem
• Function: mRNA binding; nucleotide binding