"PTK2" Related Products

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Recombinant Human PTK2 protein, MYC/DDK-tagged

Cat.No.: PTK2-90H
Product Overview: Recombinant Human PTK2, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.
Description: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only four of them have been determined.
Source: HEK293
Species: Human
Tag: MYC/DDK
Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass: 119.1 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: PTK2 PTK2 protein tyrosine kinase 2 [ Homo sapiens ]
Official Symbol: PTK2
Synonyms: PTK2; PTK2 protein tyrosine kinase 2; focal adhesion kinase 1; FADK; FAK; FAK1; PPP1R71; protein phosphatase 1; regulatory subunit 71; FADK 1; FAK-related non-kinase polypeptide; focal adhesion kinase-related nonkinase; protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; FRNK; p125FAK; pp125FAK;
Gene ID: 5747
mRNA Refseq: NM_153831
Protein Refseq: NP_722560
MIM: 600758
UniProt ID: Q05397
Chromosome Location: 8q24.3
Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Axon guidance, organism-specific biosystem;
Function: ATP binding; JUN kinase binding; SH2 domain binding; binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein tyrosine kinase activity; signal transducer activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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