Recombinant Human PTPRB, GST-tagged

• Cat.No.: PTPRB-1859H
• Product Overview: Recombinant human PTPRB protein(1675-1996) with N-terminal GST tag was expressed in anE.coliexpression system, MW= 63.7 kDa.

Specification

• Cat. No.: PTPRB-1859H
• Description: Receptor-type tyrosine-protein phosphatase beta is an enzyme that in humans is encoded by the PTPRB gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
• Source: E.coli.
• Formulation: 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
• Purity: > 95% by SDS-PAGE.
• Specific Activity: 40 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP.
• Application: Useful for the study of enzyme kinetics, regulation, and to dephosphorylate target substrates.
• Storage: >6 months at –80°C.
• Pathways: Adherens junction

Gene Information

• Gene Name: PTPRB protein tyrosine phosphatase, receptor type, B [ Homo sapiens ]
• Synonyms: protein tyrosine phosphatase, receptor type, B; PTPB; HPTPB; VEPTP; FLJ44133; MGC59935; HPTP-BETA; MGC142023; R-PTP-BETA; DKFZp686E2262; DKFZp686H15164; PTPRB; receptor-type tyrosine-protein phosphatase beta;VE-PTP; EC 3.1.3.48; protein-tyrosine phosphatase beta; vascular endothelial protein tyrosine phosphatase; protein tyrosine phosphatase, receptor type, beta polypeptide;R-PTP-beta;Protein-tyrosine phosphatase beta
• Gene ID: 5787
• mRNA Refseq: NM_001109754
• Protein Refseq: NP_001103224
• MIM: 176882
• UniProt ID: P23467
• Chromosome Location: 12q15-q21
• Function: hydrolase activity; protein binding; transmembrane receptor protein tyrosine phosphatase activity