| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
249 kDa |
| AA Sequence : |
MEAEFYMVILTCLIFRNSEGFQIVH VQKQQCLFKNEKVVVGSCNRTIQNQ QWMWTEDEKLLHVKSALCLAISNSS RGPSRSAILDRCSQAPRWTCYDQEG FLEVENASLFLQKQGSRVVVKKARK YLHSWMKIDVNKEGKLVNESLCLQK AGLGAEVSVRSTRNTAPPQILTTFN AVPDGLVFLIRNTTEAFIRNAAENY SQNSSERQHPNLHMTGITDTSWVLS TTQPFSSTTEETGLAEPERCNFTLA ESKASSHSVSIQWRILGSPCNFSLI YSSDTLGAALCPTFRIDNTTYGCNL QDLQAGTIYNFRIISLDEERTVVLQ TDPLPPARFGVSKEKTTSTSLHVWW TPSSGKVTSYEVQLFDENNQKIQGV QIQESTSWNEYTFFNLTAGSKYNIA ITAVSGGKRSFSVYTNGSTVPSPVK DIGISTKANSLLISWSHGSGNVERY RLMLMDKGILVHGGVVDKHATSYAF HGLTPGYLYNLTVMTEAAGLQNYRW KLVRTAPMEVSNLKVTNDGSLTSLK VKWQRPPGNVDSYNITLSHKGTIKE SRVLAPWITETHFKELVPGRLYQVT VSCVSGELSAQKMAVGRTFPDKVAN LEANNNGRMRSLVVSWSPPAGDWEQ YRILLFNDSVVLLNITVGKEETQYV MDDTGLVPGRQYEVEVIVESGNLKN SERCQGRTVPLAVLQLRVKHANETS LSIMWQTPVAEWEKYIISLADRDLL LIHKSLSKDAKEFTFTDLVPGRKYM ATVTSISGDLKNSSSVKGRTVPAQV TDLHVANQGMTSSLFTNWTQAQGDV EFYQVLLIHENVVIKNESISSETSR YSFHSLKSGSLYSVVVTTVSGGISS RQVVVEGRTVPSSVSGVTVNNSGRN DYLSVSWLLAPGDVDNYEVTLSHDG KVVQSLVIAKSVRECSFSSLTPGRL YTVTITTRSGKYENHSFSQERTVPD KVQGVSVSNSARSDYLRVSWVHATG DFDHYEVTIKNKNNFIQTKSIPKSE NECVFVQLVPGRLYSVTVTTKSGQY EANEQGNGRTIPEPVKDLTLRNRST EDLHVTWSGANGDVDQYEIQLLFND MKVFPPFHLVNTATEYRFTSLTPGR QYKILVLTISGDVQQSAFIEGFTVP SAVKNIHISPNGATDSLTVNWTPGG GDVDSYTVSAFRHSQKVDSQTIPKH VFEHTFHRLEAGEQYQIMIASVSGS LKNQINVVGRTVPASVQGVIADNAY SSYSLIVSWQKAAGVAERYDILLLT ENGILLRNTSEPATTKQHKFEDLTP GKKYKIQILTVSGGLFSKEAQTEGR TVPAAVTDLRITENSTRHLSFRWTA SEGELSWYNIFLYNPDGNLQERAQV DPLVQSFSFQNLLQGRMYKMVIVTH SGELSNESFIFGRTVPASVSHLRGS NRNTTDSLWFNWSPASGDFDFYELI LYNPNGTKKENWKDKDLTEWRFQGL VPGRKYVLWVVTHSGDLSNKVTAES RTAPSPPSLMSFADIANTSLAITWK GPPDWTDYNDFELQWLPRDALTVFN PYNNRKSEGRIVYGLRPGRSYQFNV KTVSGDSWKTYSKPIFGSVRTKPDK IQNLHCRPQNSTAIACSWIPPDSDF DGYSIECRKMDTQEVEFSRKLEKEK SLLNIMMLVPHKRYLVSIKVQSAGM TSEVVEDSTITMIDRPPPPPPHIRV NEKDVLISKSSINFTVNCSWFSDTN GAVKYFTVVVREADGSDELKPEQQH PLPSYLEYRHNASIRVYQTNYFASK CAENPNSNSKSFNIKLGAEMESLGG KCDPTQQKFCDGPLKPHTAYRISIR AFTQLFDEDLKEFTKPLYSDTFFSL PITTESEPLFGAIEGVSAGLFLIGM LVAVVALLICRQKVSHGRERPSARL SIRRDRPLSVHLNLGQKGNRKTSCP IKINQFEGHFMKLQADSNYLLSKEY EELKDVGRNQSCDIALLPENRGKNR YNNILPYDATRVKLSNVDDDPCSDY INASYIPGNNFRREYIVTQGPLPGT KDDFWKMVWEQNVHNIVMVTQCVEK GRVKCDHYWPADQDSLYYGDLILQM LSESVLPEWTIREFKICGEEQLDAH RLIRHFHYTVWPDHGVPETTQSLIQ FVRTVRDYINRSPGAGPTVVHCSAG VGRTGTFIALDRILQQLDSKDSVDI YGAVHDLRLHRVHMVQTECQYVYLH QCVRDVLRARKLRSEQENPLFPIYE NVNPEYHRDPVYSRHTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
