Recombinant Human PTPRO Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PTPRO-6718H
• Product Overview: PTPRO MS Standard C13 and N15-labeled recombinant protein (NP_109596) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 47.2 kDa
• AA Sequence: Tag(s)MVTEMNPNVVVISVLAILSTLLIGL LLVTLIILRKKHLQMARECGAGTFV NFASLERDGKLPYNWRRSIFAFLTL LPSCLWTDYLLAFYINPWSKNGLKK RKLTNPVQLDDFDAYIKDMAKDSDY KFSLQFEELKLIGLDIPHFAADLPL NRCKNRYTNILPYDFSRVRLVSMNE EEGADYINANYIPGYNSPQEYIATQ GPLPETRNDFWKMVLQQKSQIIVML TQCNEKRRVKCDHYWPFTEEPIAYG DITVEMISEEEQDDWACRHFRINYA DEMQDVMHFNYTAWPDHGVPTANAA ESILQFVHMVRQQATKSKGPMIIHC SAGVGRTGTFIALDRLLQHIRDHEF VDILGLVSEMRSYRMSMVQTEEQYI FIHQCVQLMWMKKKQQFCISDVIYE NVSKSTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PTPRO protein tyrosine phosphatase receptor type O [ Homo sapiens (human) ]
• Official Symbol: PTPRO
• Synonyms: PTPRO; protein tyrosine phosphatase, receptor type, O; receptor-type tyrosine-protein phosphatase O; GLEPP1; NPHS6; osteoclastic transmembrane protein tyrosine phosphatase; PTP oc; PTP U2; PTPU2; PTP phi; PTPase U2; phosphotyrosine phosphatase U2; glomerular epithelial protein 1; protein tyrosine phosphatase PTP-U2; osteoclastic transmembrane protein-tyrosine phosphatase; PTP-OC; PTP-U2; PTPROT; R-PTP-O
• Gene ID: 5800
• mRNA Refseq: NM_030671
• Protein Refseq: NP_109596
• MIM: 600579
• UniProt ID: Q16827