Recombinant Human PTRF Protein, MYC/DDK-tagged

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Recombinant Human PTRF Protein, MYC/DDK-tagged

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Cat.No. : PTRF-3163H
Product Overview : Recombinant Human PTRF protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
Description : This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 43.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : PTRF polymerase I and transcript release factor [ Homo sapiens ]
Official Symbol : PTRF
Synonyms : CAVIN; cavin-1; CAVIN1; CGL4; FKSG13
Gene ID : 284119
mRNA Refseq : NM_012232
Protein Refseq : NP_036364
MIM : 603198
UniProt ID : Q6NZI2

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