Recombinant Human RABGAP1L Protein, MYC/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | RABGAP1L-134H |
| Product Overview : | RABGAP1L MS Standard C13 and N15-labeled recombinant protein (NP_055672) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP. Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 92.3 kDa |
| AA Sequence : | MEVRASLQKV SGSSDSVATM NSEEFVLVPQ YADDNSTKHE EKPQLKIVSN GDEQLEKAME EILRDSEKRP SSLLVDCQSS SEISDHSFGD IPASQTNKPS LQLILDPSNT EISTPRPSSP GGLPEEDSVL FNKLTYLGCM KVSSPRNEVE ALRAMATMKS SSQYPFPVTL YVPNVPEGSV RIIDQSSNVE IASFPIYKVL FCARGHDGTT ESNCFAFTES SHGSEEFQIH VFSCEIKEAV SRILYSFCTA FKRSSRQVSD VKDSVIPTPD SDVFTFSVSL EVKEDDGKGN FSPVPKDRDK FYFKLKQGIE KKVVITVQQL SNKELAIERC FGMLLSPGRN VKNSDMHLLD MESMGKSYDG RAYVITGMWN PNAPVFLALN EETPKDKQVY MTVAVDMVVT EVVEPVRFLL ETVVRVYPAN ERFWYFSRKT FTETFFMRLK QSEGKGHTNA GDAIYEVVSL QRESDKEEPV TPTSGGGPMS PQDDEAEEES DNELSSGTGD VSKDCPEKIL YSWGELLGKW HSNLGARPKG LSTLVKSGVP EALRAEVWQL LAGCHDNQAM LDRYRILITK DSAQESVITR DIHRTFPAHD YFKDTGGDGQ ESLYKICKAY SVYDEDIGYC QGQSFLAAVL LLHMPEEQAF CVLVKIMYDY GLRDLYRNNF EDLHCKFYQL ERLMQEQLPD LHSHFSDLNL EAHMYASQWF LTLFTAKFPL CMVFHIIDLL LCEGLNIIFH VALALLKTSK EDLLQADFEG ALKFFRVQLP KRYRAEENAR RLMEQACNIK VPTKKLKKYE KEYQTMRESQ LQQEDPMDRY KFVYLTRTRP LEQKLISEED LAANDILDYK DDDDKV |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | RABGAP1L RAB GTPase activating protein 1 like [ Homo sapiens (human) ] |
| Official Symbol : | RABGAP1L |
| Synonyms : | RABGAP1L; RAB GTPase activating protein 1 like; HHL; TBC1D18; rab GTPase-activating protein 1-like; TBC1 domain family, member 18; expressed in hematopoietic cells, heart, liver (HLL) |
| Gene ID : | 9910 |
| mRNA Refseq : | NM_014857 |
| Protein Refseq : | NP_055672 |
| MIM : | 609238 |
| UniProt ID : | Q5R372 |
◆ Recombinant Protein
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