Recombinant Human RAPGEF5 cell lysate

• Cat.No.: RAPGEF5-1469HCL

Specification

• Description: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 [ Homo sapiens ]
• Official Symbol: RAPGEF5
• Synonyms: RAPGEF5; Rap guanine nucleotide exchange factor (GEF) 5; rap guanine nucleotide exchange factor 5; GFR; KIAA0277; M Ras regulated GEF; MR GEF; related to Epac; M-Ras-regulated GEF; M-Ras-regulated Rap GEF; guanine nucleotide exchange factor for Rap1; REPAC; MR-GEF
• Gene ID: 9771
• mRNA Refseq: NM_012294
• Protein Refseq: NP_036426
• MIM: 609527
• UniProt ID: Q92565
• Chromosome Location: 7p15.3
• Function: GTP-dependent protein binding; Rap guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity