Recombinant Human RBFOX1 Protein, His-tagged

• Cat.No.: RBFOX1-657H
• Product Overview: Recombinant human RBFOX1 protein, fused to His tag at N-terminus, was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
• Form: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
• Molecular Mass: 42.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: RNA binding protein, fox-1 homolog 1[ Homo sapiens ]
• Official Symbol: RBFOX1
• Synonyms: 2BP1; A2BP1; FOX-1; FOX1; HRNBP1
• Gene ID: 54715
• mRNA Refseq: NM_018723.3
• Protein Refseq: NP_061193.2
• MIM: 605104
• UniProt ID: Q9NWB1