Recombinant Human RBFOX3 Protein, His tagged

• Cat.No.: RBFOX3-09H
• Product Overview: Purified recombinant protein of Human RNA binding protein, fox-1 homolog (C. elegans) 3 (RBFOX3), Met1-Asn185, with N-terminal His tag, expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-185 aa
• Description: This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
• Molecular Mass: 22.7 kDa
• Purity: > 90% as determined by SDS-PAGE and Coomassie blue staining
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Concentration: > 50 μg/mL as determined by microplate Bradford method
• Shipping: Dry Ice
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, 8M Urea

Gene Information

• Gene Name: RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 [ Homo sapiens (human) ]
• Official Symbol: RBFOX3
• Synonyms: RBFOX3; RNA binding protein, fox-1 homolog (C. elegans) 3; RNA binding protein fox-1 homolog 3; FOX 3; hexaribonucleotide binding protein 3; HRNBP3; NeuN; neuronal nuclei; fox-1 homolog C; FOX3; NEUN; FOX-3; FLJ56884; FLJ58356
• Gene ID: 146713
• mRNA Refseq: NM_001082575
• Protein Refseq: NP_001076044
• MIM: 616999
• UniProt ID: A6NFN3