Recombinant Human RBM8A Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human RBM8A Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : RBM8A-684H
Product Overview : RBM8A MS Standard C13 and N15-labeled recombinant protein (NP_005096) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 19.7 kDa
AA Sequence : MADVLDLHEA GGEDFAMDED GDESIHKLKE KAKKRKGRGF GSEEGSRARM REDYDSVEQD GDEPGPQRSV EGWILFVTGV HEEATEEDIH DKFAEYGEIK NIHLNLDRRT GYLKGYTLVE YETYKEAQAA MEGLNGQDLM GQPISVDWCF VRGPPKGKRR GGRRRSRSPD RRRRTRTRPL EQKLISEEDL AANDILDYKD DDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : RBM8A RNA binding motif protein 8A [ Homo sapiens (human) ]
Official Symbol : RBM8A
Synonyms : RBM8A; RNA binding motif protein 8A; RBM8; RNA-binding protein 8A; BOV 1A; BOV 1B; BOV 1C; RBM8B; Y14; ZNRP; BOV-1; binder of OVCA1-1; ribonucleoprotein RBM8; RNA-binding protein Y14; ribonucleoprotein RBM8A; RNA binding motif protein 8B; RNA-binding motif protein 8A; TAR; ZRNP1; BOV-1A; BOV-1B; BOV-1C; MDS014; DEL1q21.1; C1DELq21.1;
Gene ID : 9939
mRNA Refseq : NM_005105
Protein Refseq : NP_005096
MIM : 605313
UniProt ID : Q9Y5S9

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