Recombinant Human Relaxin 3

• Cat.No.: RLN3-115H
• Product Overview: Recombinant Human Relaxin-3 produced inE.coliis a 5.5 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 27 amino acid B-chain.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Relaxin-3 (H3 relaxin, Insulin-like peptide-7, INSL7) is a secreted protein structurally related to insulin, which is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor, previously known as "somatostatin-like" or "angiotensin-like" peptide receptor, and also binds specifically to the LGR7 receptor, previously identified as an "orphan" G protein coupled receptor. Signaling by Relaxin-3 through its target receptors is, most likely, part of a CNS processing system, activated in response to signaling by neuropeptides and other factors. Intracerebroventricular injections of Relaxin-3 have been shown to cause a significant increase of food intake and body weight in Wistar rats.
• Purity: 98 % (SDS-PAGE, HPLC).
• Endotoxin Level: < 0.1 ng per ug of Relaxin-3.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biological Activity: Data not available!
• Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted Relaxin-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: RLN3 relaxin 3 [ Homo sapiens ]
• Synonyms: RLN3; relaxin 3; H3; RXN3; ZINS4; insl7; 19p13.2; relaxin 3 (H3); Relaxin-3; Prorelaxin H3; Insulin-like peptide INSL7; Insulin-like peptide 7; Relaxin-3 B chain;Relaxin-3 A chain; UNQ6188/PRO20213
• Gene ID: 117579
• mRNA Refseq: NM_080864
• Protein Refseq: NP_543140
• MIM: 606855
• UniProt ID: Q8WXF3
• Chromosome Location: 1q21
• Function: G-protein-coupled receptor binding; hormone activity