Recombinant Full Length Human RFWD2 protein, Isoform 1

• Cat.No.: RFWD2-186H
• Product Overview: Recombinant Human RFWD2, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Protein Length: 1-731 a.a.
• Description: RFWD2 played an important role in many functions.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 80.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Publications:
  Imaging and kinetics of the bimolecular complex formed by the tumor suppressor p53 with ubiquitin ligase COP1 as studied by atomic force microscopy and surface plasmon resonance (2018)

Gene Information

• Gene Name: RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase [ Homo sapiens ]
• Official Symbol: RFWD2
• Synonyms: RFWD2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; ring finger and WD repeat domain 2; E3 ubiquitin-protein ligase RFWD2; COP1; FLJ10416; RNF200; hCOP1; RING finger protein 200; putative ubiquitin ligase COP1; RING finger and WD repeat domain protein 2; constitutive photomorphogenic protein (COP1); constitutive photomorphogenesis protein 1 homolog; RP11-318C24.3
• Gene ID: 64326
• mRNA Refseq: NM_022457
• Protein Refseq: NP_071902
• MIM: 608067
• UniProt ID: Q8NHY2
• Chromosome Location: 1q25.1-q25.2
• Pathway: Autodegradation of the E3 ubiquitin ligase COP1, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; G1/S DNA Damage Checkpoints, organism-specific biosystem; Stabilization of p53, organism-specific biosystem; Ubiquitin mediated proteolysis, organism-specific biosystem
• Function: ligase activity; metal ion binding; protein binding; zinc ion binding