Recombinant Human RIOK1 Protein (D2-K568), His/GST tagged

• Cat.No.: RIOK1-0600H
• Product Overview: Recombinant Human 8His-GST-TEV-GG-RIOK1(D2-K568 end) Protein was expressed in Insect cell.

Specification

• Description: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation.
• Source: Insect cell
• Species: Human
• Tag: His/GST
• Form: Liquid
• Protein Length: D2-K568
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: RIOK1 RIO kinase 1 (yeast) [ Homo sapiens (human) ]
• Official Symbol: RIOK1
• Synonyms: RIOK1; RIO kinase 1 (yeast); serine/threonine-protein kinase RIO1; AD034; bA288G3.1; FLJ30006; RRP10; MGC12903
• Gene ID: 83732
• mRNA Refseq: NM_031480
• Protein Refseq: NP_113668
• UniProt ID: Q9BRS2