Recombinant Human RIPK3 Protein (1-518 aa), His-tagged
Cat.No. : | RIPK3-1756H |
Product Overview : | Recombinant Human RIPK3 Protein (1-518 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cell Biology. Protein Description: Full Length. |
- Specification
- Gene Information
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Description : | Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. |
Source : | Yeast |
Species : | Human |
Tag : | His |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 58.9 kDa |
Protein length : | 1-518 aa |
AA Sequence : | MSCVKLWPSGAPAPLVSIEELENQE LVGKGGFGTVFRAQHRKWGYDVAVK IVNSKAISREVKAMASLDNEFVLRL EGVIEKVNWDQDPKPALVTKFMENG SLSGLLQSQCPRPWPLLCRLLKEVV LGMFYLHDQNPVLLHRDLKPSNVLL DPELHVKLADFGLSTFQGGSQSGTG SGEPGGTLGYLAPELFVNVNRKAST ASDVYSFGILMWAVLAGREVELPTE PSLVYEAVCNRQNRPSLAELPQAGP ETPGLEGLKELMQLCWSSEPKDRPS FQECLPKTDEVFQMVENNMNAAVST VKDFLSQLRSSNRRFSIPESGQGGT EMDGFRRTIENQHSRNDVMVSEWLN KLNLEEPPSSVPKKCPSLTKRSRAQ EEQVPQAWTAGTSSDSMAQPPQTPE TSTFRNQMPSPTSTGTPSPGPRGNQ GAERQGMNWSCRTPEPNPVTGRPLV NIYNCSGVQVGDNNYLTMQQTTALP TWGLAPSGKGRGLQHPPPVGSQEGP KDPEAWSRPQGWYNHSGK |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with reconstitution instruction is sent along with the products. |
Gene Name : | RIPK3 receptor-interacting serine-threonine kinase 3 [ Homo sapiens ] |
Official Symbol : | RIPK3 |
Synonyms : | RIPK3; RIP3; RIP-3; RIP-like protein kinase 3; |
Gene ID : | 11035 |
mRNA Refseq : | NM_006871 |
Protein Refseq : | NP_006862 |
MIM : | 605817 |
UniProt ID : | Q9Y572 |
Products Types
◆ Recombinant Protein | ||
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RIPK3-1143H | Recombinant Human RIPK3 Protein (S2-K518), His/GST tagged | +Inquiry |
RIPK3-1723M | Recombinant Mouse RIPK3 Protein (1-486 aa), His-tagged | +Inquiry |
RIPK3-1142H | Recombinant Human RIPK3 Protein (S2-K518), Tag Free | +Inquiry |
Ripk3-2349R | Recombinant Rat Ripk3 protein, His&Myc-tagged | +Inquiry |
◆ Lysates | ||
RIPK3-2332HCL | Recombinant Human RIPK3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionRIPK3 activation can lead to the release of pro-inflammatory cytokines, contributing to inflammation in various tissues.
Yes, researchers are exploring the therapeutic potential of targeting RIPK3 to modulate cell death pathways and control inflammation in diseases.
Yes, dysregulation of RIPK3 is linked to several diseases, including neurodegenerative disorders, inflammatory diseases, and certain types of cancers.
In certain cancers, RIPK3 dysregulation can promote cell survival, contributing to tumor growth and resistance to cell death.
Yes, some clinical trials are investigating drugs that target RIPK3 for conditions such as inflammatory diseases and cancer.
Customer Reviews (3)
Write a reviewTheir team of experts possesses an in-depth understanding of the protein and its applications, which proves instrumental in troubleshooting and optimizing experimental protocols.
The manufacturer's responsive and knowledgeable support system promptly addresses any questions or concerns I may have, greatly streamlining my research process.
the manufacturer's dedication to innovation and continuous improvement stands out.
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