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Recombinant Human RIPK3 Protein (1-518 aa), His-tagged

Cat.No. : RIPK3-1756H
Product Overview : Recombinant Human RIPK3 Protein (1-518 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cell Biology. Protein Description: Full Length.
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  • Gene Information
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Description : Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Source : Yeast
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 58.9 kDa
Protein length : 1-518 aa
AA Sequence : MSCVKLWPSGAPAPLVSIEELENQE LVGKGGFGTVFRAQHRKWGYDVAVK IVNSKAISREVKAMASLDNEFVLRL EGVIEKVNWDQDPKPALVTKFMENG SLSGLLQSQCPRPWPLLCRLLKEVV LGMFYLHDQNPVLLHRDLKPSNVLL DPELHVKLADFGLSTFQGGSQSGTG SGEPGGTLGYLAPELFVNVNRKAST ASDVYSFGILMWAVLAGREVELPTE PSLVYEAVCNRQNRPSLAELPQAGP ETPGLEGLKELMQLCWSSEPKDRPS FQECLPKTDEVFQMVENNMNAAVST VKDFLSQLRSSNRRFSIPESGQGGT EMDGFRRTIENQHSRNDVMVSEWLN KLNLEEPPSSVPKKCPSLTKRSRAQ EEQVPQAWTAGTSSDSMAQPPQTPE TSTFRNQMPSPTSTGTPSPGPRGNQ GAERQGMNWSCRTPEPNPVTGRPLV NIYNCSGVQVGDNNYLTMQQTTALP TWGLAPSGKGRGLQHPPPVGSQEGP KDPEAWSRPQGWYNHSGK
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : RIPK3 receptor-interacting serine-threonine kinase 3 [ Homo sapiens ]
Official Symbol : RIPK3
Synonyms : RIPK3; RIP3; RIP-3; RIP-like protein kinase 3;
Gene ID : 11035
mRNA Refseq : NM_006871
Protein Refseq : NP_006862
MIM : 605817
UniProt ID : Q9Y572

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does RIPK3 contribute to inflammatory processes? 04/17/2023

RIPK3 activation can lead to the release of pro-inflammatory cytokines, contributing to inflammation in various tissues.

Can RIPK3 be a potential therapeutic target? 01/11/2022

Yes, researchers are exploring the therapeutic potential of targeting RIPK3 to modulate cell death pathways and control inflammation in diseases.

Are there any diseases associated with dysregulation of RIPK3? 06/12/2020

Yes, dysregulation of RIPK3 is linked to several diseases, including neurodegenerative disorders, inflammatory diseases, and certain types of cancers.

How does RIPK3 contribute to cancer development? 03/10/2020

In certain cancers, RIPK3 dysregulation can promote cell survival, contributing to tumor growth and resistance to cell death.

Are there any clinical trials targeting RIPK3 for therapeutic purposes? 06/11/2016

Yes, some clinical trials are investigating drugs that target RIPK3 for conditions such as inflammatory diseases and cancer.

Customer Reviews (3)

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Reviews
03/27/2023

    Their team of experts possesses an in-depth understanding of the protein and its applications, which proves instrumental in troubleshooting and optimizing experimental protocols.

    08/24/2020

      The manufacturer's responsive and knowledgeable support system promptly addresses any questions or concerns I may have, greatly streamlining my research process.

      07/28/2017

        the manufacturer's dedication to innovation and continuous improvement stands out.

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