Recombinant Human RNASEH2A Protein, MYC/DDK-tagged

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Recombinant Human RNASEH2A Protein, MYC/DDK-tagged

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Cat.No. : RNASEH2A-1257H
Product Overview : Recombinant human RNASEH2A protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
Description : The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 33.2 kDa
Purity : >50 ug/mL as determined by microplate BCA method
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : RNASEH2A ribonuclease H2, subunit A [ Homo sapiens ]
Official Symbol : RNASEH2A
Synonyms : AGS4; JUNB; RNASEHI; RNHIA; RNHL
Gene ID : 10535
mRNA Refseq : NM_006397
Protein Refseq : NP_006388
MIM : 606034
UniProt ID : O75792

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