Recombinant Human RNF11 Protein (G2-N154), His tagged

• Cat.No.: RNF11-0460H
• Product Overview: Recombinant Human 6His-TEV-(GG)-RNF11(G2-N154 end) Protein was expressed in E. coli.

Specification

• Description: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: G2-N154
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: RNF11 ring finger protein 11 [ Homo sapiens (human) ]
• Official Symbol: RNF11
• Synonyms: RNF11; ring finger protein 11; RING finger protein 11; CGI 123; MGC51169; Sid1669p; CGI-123; SID1669
• Gene ID: 26994
• mRNA Refseq: NM_014372
• Protein Refseq: NP_055187
• MIM: 612598
• UniProt ID: Q9Y3C5