| Description : |
This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
118.4 kDa |
| AA Sequence : |
MECPSCQHVSKEETPKFCSQCGERL PPAAPIADSENNNSTMASASEGEME CGQELKEEGGPCLFPGSDSWQENPE EPCSKASWTVQESKKKKRKKKKKGN KSASSELASLPLSPASPCHLTLLSN PWPQDTALPHSQAQQSGPTGQPSQP PGTATTPLEGDGLSAPTEVGDSPLQ AQALGEAGVATGSEAQSSPQFQDHT EGEDQDASIPSGGRGLSQEGTGPPT SAGEGHSRTEDAAQELLLPESKGGS SEPGTELQTTEQQAGASASTAVDAV AEPANAVKGAGKEMKEKTQRMKQPP ATTPPFKTHCQEAETKTKDETAAAE EKVGKNEQGEPEDLKKPEGKNRSAA AVKNEKEQKNQEADVQEVKASTLSP GGGVTVFFHAIISLHFPFNPDLHKV FIRGGEEFGESKWDSNICELHYTRD LGHDRVLVEGIVCISKKHLDKYIPY KYVIYNGESFEYEFIYKHQQKKGEY VNRCLFIKSSLLGSGDWHQYYDIVY MKPHGRLQKVMNHITDGPRKDLVKG KQIAAALMLDSTFSILQTWDTINLN SFFTQFEQFCFVLQQPMIYEGQAQL WTDLQYREKEVKRYLWQHLKKHVVP LPDGKSTDFLPVDCPVRSKLKTGLI VLFVVEKIELLLEGSLDWLCHLLTS DASSPDEFHRDLSHILGIPQSWRLY LVNLCQRCMDTRTYTWLGALPVLHC CMELAPRHKDAWRQPEDTWAALEGL SFSPFREQMLDTSSLLQFMREKQHL LSIDEPLFRSWFSLLPLSHLVMYME NFIEHLGRFPAHILDCLSGIYYRLP GLEQVLNTQDVQDVQNVQNILEMLL RLLDTYRDKIPEEALSPSYLTVCLK LHEAICSSTKLLKFYELPALSAEIV CRMIRLLSLVDSAGQRDETGNNSVQ TVFQGTLAATKRWLREVFTKNMLTS SGASFTYVKEIEVWRRLVEIQFPAE HGWKESLLGDMEWRLTKEEPLSQIT AYCNSCWDTKGLEDSVAKTFEKCII EAVSSACQVNNLSSWETDSGSQLCS AMTQLRAMKHPLGLSSSANSEIGKW APSSLAKGNGAEITRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
